{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nagy Z"],"funding":["British Heart Foundation","Medical Research Council"],"pagination":["331-343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6484457"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["133(4)"],"pubmed_abstract":["Conditional knockout (KO) mouse models are invaluable for elucidating the physiological roles of platelets. The <i>Platelet factor 4-Cre recombinase</i> (<i>Pf4-Cre</i>) transgenic mouse is the current model of choice for generating megakaryocyte/platelet-specific KO mice. Platelets and leukocytes work closely together in a wide range of disease settings, yet the specific contribution of platelets to these processes remains unclear. This is partially a result of the <i>Pf4-Cre</i> transgene being expressed in a variety of leukocyte populations. To overcome this issue, we developed a <i>Gp1ba-Cre</i> transgenic mouse strain in which <i>Cre</i> expression is driven by the endogenous <i>Gp1ba</i> locus. By crossing <i>Gp1ba-Cre</i> and <i>Pf4-Cre</i> mice to the <i>mT/mG</i> dual-fluorescence"],"journal":["Blood"],"pubmed_title":["The <i>Gp1ba-Cre</i> transgenic mouse: a new model to delineate platelet and leukocyte functions."],"pmcid":["PMC6484457"],"funding_grant_id":["FS/13/1/29894","RG/15/13/31673","GBT1564","FS/15/58/31784"],"pubmed_authors":["Vogtle T","Gareus R","Di Nunzio G","Geer MJ","Tarakhovsky A","Neel BG","Desanti GE","Weiss A","Senis YA","Mazharian A","Heising S","Mori J","Nagy Z"],"additional_accession":[]},"is_claimable":false,"name":"The <i>Gp1ba-Cre</i> transgenic mouse: a new model to delineate platelet and leukocyte functions.","description":"Conditional knockout (KO) mouse models are invaluable for elucidating the physiological roles of platelets. The <i>Platelet factor 4-Cre recombinase</i> (<i>Pf4-Cre</i>) transgenic mouse is the current model of choice for generating megakaryocyte/platelet-specific KO mice. Platelets and leukocytes work closely together in a wide range of disease settings, yet the specific contribution of platelets to these processes remains unclear. This is partially a result of the <i>Pf4-Cre</i> transgene being expressed in a variety of leukocyte populations. To overcome this issue, we developed a <i>Gp1ba-Cre</i> transgenic mouse strain in which <i>Cre</i> expression is driven by the endogenous <i>Gp1ba</i> locus. By crossing <i>Gp1ba-Cre</i> and <i>Pf4-Cre</i> mice to the <i>mT/mG</i> dual-fluorescence","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-04-29T01:16:59.046Z","creation":"2025-05-29T19:47:28.977Z"},"accession":"S-EPMC6484457","cross_references":{"pubmed":["30429161"],"doi":["10.1182/blood-2018-09-877787"]}}