{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Colli DF"],"funding":["American Heart Association","NHLBI NIH HHS","National Institutes of Health","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["1386-1393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6486484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(8)"],"pubmed_abstract":["In mammalian ventricular cardiomyocytes, invaginations of the surface membrane form the transverse tubular system (T-system), which consists of transverse tubules (TTs) that align with sarcomeres and Z-lines as well as longitudinal tubules (LTs) that are present between Z-lines in some species. In many cardiac disease etiologies, the T-system is perturbed, which is believed to promote spatially heterogeneous, dyssynchronous Ca<sup>2+</sup> release and inefficient contraction. In general, T-system characterization approaches have been directed primarily at isolated cells and do not detect subcellular T-system heterogeneity. Here, we present MatchedMyo, a matched-filter-based algorithm for subcellular T-system characterization in isolated cardiomyocytes and millimeter-scale myocardial sectio"],"journal":["Biophysical journal"],"pubmed_title":["A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues."],"pmcid":["PMC6486484"],"funding_grant_id":["P20 GM103527","P30 GM127211","R01 HL132067","R35GM124977","R35 GM124977","P20GM103527","17UFEL33490002"],"pubmed_authors":["Louch WE","Sachse FB","Blood SR","Sankarankutty AC","Frisk M","Colli DF","Kekenes-Huskey PM"],"additional_accession":[]},"is_claimable":false,"name":"A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues.","description":"In mammalian ventricular cardiomyocytes, invaginations of the surface membrane form the transverse tubular system (T-system), which consists of transverse tubules (TTs) that align with sarcomeres and Z-lines as well as longitudinal tubules (LTs) that are present between Z-lines in some species. In many cardiac disease etiologies, the T-system is perturbed, which is believed to promote spatially heterogeneous, dyssynchronous Ca<sup>2+</sup> release and inefficient contraction. In general, T-system characterization approaches have been directed primarily at isolated cells and do not detect subcellular T-system heterogeneity. Here, we present MatchedMyo, a matched-filter-based algorithm for subcellular T-system characterization in isolated cardiomyocytes and millimeter-scale myocardial sectio","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-06-04T02:17:06.2Z","creation":"2021-02-21T08:49:38Z"},"accession":"S-EPMC6486484","cross_references":{"pubmed":["30979553"],"doi":["10.1016/j.bpj.2019.03.010"]}}