biostudies-literatureUnknown41(3)Najjar RSJohnsie and Aubary Montgomery Institute of Medical Education and Research<h4>Background</h4>Cardiovascular disease (CVD) is a major economic burden in the United States. CVD risk factors, particularly hypertension and hypercholesterolemia, are typically treated with drug therapy. Five-year efficacy of such drugs to prevent CVD is estimated to be 5%. Plant-based diets have emerged as effective mitigators of these risk factors.<h4>Hypothesis</h4>The implementation of a defined, plant-based diet for 4 weeks in an outpatient clinical setting may mitigate CVD risk factors and reduce patient drug burden.<h4>Methods</h4>Participants consumed a plant-based diet consisting of foods prepared in a defined method in accordance with a food-classification system. Participants consumed raw fruits, vegetables, seeds, and avocado. All animal products were excluded from the dietClinical cardiology307-313https://www.ebi.ac.uk/biostudies/studies/S-EPMC6489725biostudies-literatureA defined, plant-based diet utilized in an outpatient cardiovascular clinic effectively treats hypercholesterolemia and hypertension and reduces medications.PMC6489725Najjar RSMontgomery BDMoore CEfalseA defined, plant-based diet utilized in an outpatient cardiovascular clinic effectively treats hypercholesterolemia and hypertension and reduces medications.<h4>Background</h4>Cardiovascular disease (CVD) is a major economic burden in the United States. CVD risk factors, particularly hypertension and hypercholesterolemia, are typically treated with drug therapy. Five-year efficacy of such drugs to prevent CVD is estimated to be 5%. Plant-based diets have emerged as effective mitigators of these risk factors.<h4>Hypothesis</h4>The implementation of a defined, plant-based diet for 4 weeks in an outpatient clinical setting may mitigate CVD risk factors and reduce patient drug burden.<h4>Methods</h4>Participants consumed a plant-based diet consisting of foods prepared in a defined method in accordance with a food-classification system. Participants consumed raw fruits, vegetables, seeds, and avocado. All animal products were excluded from the diet2018-01-01T00:00:00Z2018 Mar2025-04-04T08:24:10.354Z2019-09-04T07:03:23ZS-EPMC64897252957500210.1002/clc.22863