{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(11)"],"submitter":["Dorr O"],"pubmed_abstract":["Background
Compromised renal function is a major risk factor that is strongly associated with poor outcome in patients with mitral regurgitation (MR) and heart failure. Cystatin C, a cysteine protease inhibitor, has been used as a specific and sensitive biomarker of renal function. Neutrophil gelatinase-associated lipocalin (NGAL) is another sensitive biomarker that specifically indicates functional and structural kidney damage. The aim of the present study was to determine the predictive value of serum cystatin C and urinary NGAL as indicators of mortality in patients undergoing percutaneous mitral valve repair (PMVR).Methods
A total of 120 consecutive patients (age: 77.3 years [±11.2]) undergoing PMVR using the MitraClip system were included in this study. Venous blood an"],"journal":["Clinical cardiology"],"pagination":["1474-1479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6489940"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of cystatin C and neutrophil gelatinase-associated lipocalin as predictors of mortality in patients undergoing percutaneous mitral valve repair (MitraClip)."],"pmcid":["PMC6489940"],"pubmed_authors":["Dorr O","Keller T","Hamm CW","Ortlieb RM","Gaede L","Troidl C","Boeder N","Nef H","Bauer P","Liebetrau C","Mollmann H","Walther C","Bauer T","Voss S"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of cystatin C and neutrophil gelatinase-associated lipocalin as predictors of mortality in patients undergoing percutaneous mitral valve repair (MitraClip).","description":"Background
Compromised renal function is a major risk factor that is strongly associated with poor outcome in patients with mitral regurgitation (MR) and heart failure. Cystatin C, a cysteine protease inhibitor, has been used as a specific and sensitive biomarker of renal function. Neutrophil gelatinase-associated lipocalin (NGAL) is another sensitive biomarker that specifically indicates functional and structural kidney damage. The aim of the present study was to determine the predictive value of serum cystatin C and urinary NGAL as indicators of mortality in patients undergoing percutaneous mitral valve repair (PMVR).Methods
A total of 120 consecutive patients (age: 77.3 years [±11.2]) undergoing PMVR using the MitraClip system were included in this study. Venous blood an","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-04-05T13:10:24.206Z","creation":"2019-09-04T07:03:28Z"},"accession":"S-EPMC6489940","cross_references":{"pubmed":["30284299"],"doi":["10.1002/clc.23089"]}}