{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang Y"],"funding":["NHLBI NIH HHS"],"pagination":["e007322"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6494091"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["The ATP-sensitive K<sup>+</sup> (K<sub>ATP</sub>) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K<sup>+</sup> channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K<sup>+</sup> channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models."],"journal":["Circulation. Arrhythmia and electrophysiology"],"pubmed_title":["Genetic Discovery of ATP-Sensitive K<sup>+</sup> Channels in Cardiovascular Diseases."],"pmcid":["PMC6494091"],"funding_grant_id":["R35 HL140024","R01 HL045742"],"pubmed_authors":["Nichols CG","Huang C","Hu D","Huang Y"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Discovery of ATP-Sensitive K<sup>+</sup> Channels in Cardiovascular Diseases.","description":"The ATP-sensitive K<sup>+</sup> (K<sub>ATP</sub>) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K<sup>+</sup> channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K<sup>+</sup> channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2024-02-15T09:44:00.144Z","creation":"2020-05-22T18:58:40Z"},"accession":"S-EPMC6494091","cross_references":{"pubmed":["31030551"],"doi":["10.1161/CIRCEP.119.007322","10.1161/circep.119.007322"]}}