biostudies-literatureHuang YNHLBI NIH HHSe007322https://www.ebi.ac.uk/biostudies/studies/S-EPMC6494091biostudies-literatureUnknown12(5)The ATP-sensitive K⁺ (K_ATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K⁺ channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K⁺ channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.Circulation. Arrhythmia and electrophysiologyGenetic Discovery of ATP-Sensitive K⁺ Channels in Cardiovascular Diseases.PMC6494091R35 HL140024R01 HL045742Nichols CGHuang CHu DHuang YfalseGenetic Discovery of ATP-Sensitive K⁺ Channels in Cardiovascular Diseases.The ATP-sensitive K⁺ (K_ATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K⁺ channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K⁺ channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.2019-01-01T00:00:00Z2019 May2024-02-15T09:44:00.144Z2020-05-22T18:58:40ZS-EPMC64940913103055110.1161/CIRCEP.119.00732210.1161/circep.119.007322