{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Panas MW"],"funding":["HHS | National Institutes of Health","Human Frontier Science Program","NIAID NIH HHS","NCI NIH HHS","National Science Foundation"],"pagination":["e00674-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6495377"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(2)"],"pubmed_abstract":["<i>Toxoplasma gondii</i> is an obligate intracellular parasite that establishes a favorable environment in the host cells in which it replicates. We have previously reported that it uses MYR-dependent translocation of dense granule proteins to elicit a key set of host responses related to the cell cycle, specifically, E2F transcription factor targets, including cyclin E. We report here the identification of a novel <i>Toxoplasma</i> effector protein that is exported from the parasitophorous vacuole in a MYR1-dependent manner and localizes to the host's nucleus. Parasites lacking this inducer of <u>h</u>ost <u>c</u>yclin <u>E</u> (HCE1) are unable to modulate E2F transcription factor target genes and exhibit a substantial growth defect. Immunoprecipitation of HCE1 from infected host cells s"],"journal":["mBio"],"pubmed_title":["<i>Toxoplasma</i> Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1."],"pmcid":["PMC6495377"],"funding_grant_id":["R01 AI021423","P30 CA124435","RO1-AI021423","LT000404/2014-L","R01 AI129529","RO1-AI129529","DGE-114747"],"pubmed_authors":["Panas MW","Naor A","Cygan AM","Boothroyd JC"],"additional_accession":[]},"is_claimable":false,"name":"<i>Toxoplasma</i> Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1.","description":"<i>Toxoplasma gondii</i> is an obligate intracellular parasite that establishes a favorable environment in the host cells in which it replicates. We have previously reported that it uses MYR-dependent translocation of dense granule proteins to elicit a key set of host responses related to the cell cycle, specifically, E2F transcription factor targets, including cyclin E. We report here the identification of a novel <i>Toxoplasma</i> effector protein that is exported from the parasitophorous vacuole in a MYR1-dependent manner and localizes to the host's nucleus. Parasites lacking this inducer of <u>h</u>ost <u>c</u>yclin <u>E</u> (HCE1) are unable to modulate E2F transcription factor target genes and exhibit a substantial growth defect. Immunoprecipitation of HCE1 from infected host cells s","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-06-16T07:04:30.523Z","creation":"2019-06-06T23:10:28Z"},"accession":"S-EPMC6495377","cross_references":{"pubmed":["31040242"],"doi":["10.1128/mBio.00674-19"]}}