{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Itaba N"],"pubmed_abstract":["Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modalities is required to improve patient prognosis. In this study, we clarified the anti-fibrotic effects of cell sheets produced from human bone marrow-derived mesenchymal stem cells (MSCs) incubated on a temperature-sensitive culture dish with the chemical compound IC-2. Orthotopic transplantation of IC-2-engineered MSC sheets (IC-2 sheets) remarkably reduced liver fibrosis induced by chronic CCl<sub>4</sub> administration. Further, the marked production of fibrolytic enzymes su"],"journal":["Scientific reports"],"pagination":["6841"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6497888"],"repository":["biostudies-literature"],"pubmed_title":["Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets."],"pmcid":["PMC6497888"],"pubmed_authors":["Kono Y","Oka H","Yokobata T","Kakuta H","Shiota G","Morimoto M","Watanabe K","Osaki M","Itaba N"],"additional_accession":[]},"is_claimable":false,"name":"Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets.","description":"Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modalities is required to improve patient prognosis. In this study, we clarified the anti-fibrotic effects of cell sheets produced from human bone marrow-derived mesenchymal stem cells (MSCs) incubated on a temperature-sensitive culture dish with the chemical compound IC-2. Orthotopic transplantation of IC-2-engineered MSC sheets (IC-2 sheets) remarkably reduced liver fibrosis induced by chronic CCl<sub>4</sub> administration. Further, the marked production of fibrolytic enzymes su","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-18T15:28:05.976Z","creation":"2019-06-06T23:26:45Z"},"accession":"S-EPMC6497888","cross_references":{"pubmed":["31048740"],"doi":["10.1038/s41598-019-43298-0"]}}