{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karasik D"],"funding":["Cancer Research UK","NCATS NIH HHS","NCCDPHP CDC HHS","NIA NIH HHS","NHLBI NIH HHS","NNF Center for Basic Metabolic Research","National Institutes of Health","NIDDK NIH HHS","Medical Research Council","National Institute for Health Research (NIHR)","NIAMS NIH HHS","Novo Nordisk Fonden","Wellcome Trust"],"pagination":["276-287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6500901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(2)"],"pubmed_abstract":["<h4>Background</h4>Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass.<h4>Objectives</h4>To determine the impact of different fat mass adjustments on genetic architecture of LM and identify additional LM loci.<h4>Methods</h4>We performed genome-wide association analyses for whole-body LM (20 cohorts of European ancestry with n = 38,292) measured using dual-energy X-ray absorptiometry) or bioelectrical impedance analysis, adjusted for sex, age, age2, and height with or without fat mass adjustments (Model 1 no fat adjustment; Model 2 adjustment for fat m"],"journal":["The American journal of clinical nutrition"],"pubmed_title":["Disentangling the genetics of lean mass."],"pmcid":["PMC6500901"],"funding_grant_id":["R01 AG015819","NF-SI-0617-10149","NNF13OC0005785","NF-SI-0507-10228","R01 AR041398","MC_UU_12015/1","U01 AR066160","NNF14OC0010513","14136","MC_PC_13048","G1000143","MC_UU_00007/10","212945/Z/18/Z","NNF18OC0033898","NF-SI-0512-10114","U24 AG051129","MR/N003284/1","P30 AG024827","UL1 TR002369","Kilpeläinen Group","U01 DP006266","R01 DK107786","NNF17OC0026882","NF-SI-0514-10027","P30 DK020541","G0401527","R01 DK110113","R01 AG017917","R01 HL105756"],"pubmed_authors":["Jordan JM","Lindgren C","Psaty BM","Volzke H","Uitterlinden AG","Wichmann HE","Estrada K","Gudnason V","Jansson JO","Luan J","Palotie A","Nielson CM","Zhao JH","Satterfield S","Stancakova A","Newman AB","O'Connell JR","Hayward C","Stolk L","Hsu YH","Walker M","Tranah GJ","Cauley JA","Steinhagen-Thiessen E","Lorentzon M","Klopp N","Broer L","Wright NC","Harris TB","Lerch MM","Prince RL","Laakso M","Huffman KM","Thorsteinsdottir U","de Groot LCPGM","Borecki IB","Lenore LJ","Yu L","Amin N","Karlsson M","Karasik D","Salomaa V","Michaelsson K","Ripatti S","J Wareham N","Husted LB","Khaw KT","Loos RJF","Bochud M","Cho NH","Eiriksdottir G","Hofman A","Smith AV","Widen E","Peacock M","Biffar R","Econs MJ","Vandenput L","Smith SB","Campos-Obando N","Demuth I","Lill C","Raikkonen K","Zhou Y","Bertram L","Rivadeneira F","Cummings SR","Kuusisto J","Kritchevsky S","Zillikens MC","Bennett DA","Weedon MN","Streeten EA","Tikkanen E","Vollenweider P","Lewis JR","Fu M","Medina-Gomez C","Mitchell BD","Perola M","Demissie S","Mellstrom D","Grallert H","Peters A","Evans DS","Rotter JI","Thorleifsson G","Stefansson K","Thomson CA","Wactawski-Wende J","Kiel DP","Koller DL","Ohlsson C","Buchman AS","Livshits G","Wilson JF","Chen Z","Ittermann T","Malkin I","Spector TD","Mosekilde L","Meitinger T","Lahti J","Oostra BA","Kloth JSL","Langdahl BL","Barroso I","Gieger C","Ljunggren O","Choi HJ","Jula A","Yerges-Armstrong LM","Enneman AW","Eriksson JG","van Duijn CM","Melhus H","Robbins JA","Kilpelainen TO","Eriksson J","Kraus WE","McGuigan FE","Nethander M","Aghdassi A","Kutalik Z","Byberg L","Ingelsson E","Feitosa MF","Johnson T","Swart KMA","Illig T","Liu Y","Lind L","Luben RN","Styrkarsdottir U","Waterworth D","Akesson K","De Jager PL","Morris AP","Soranzo N","Shin CS","Kooner JS","Rudan I","Orwoll ES","Schipf S","Homuth G","van Schoor NM","Chou WC","Kuulasmaa T","Zhang W","Campbell H","Chambers JC","Thompson P","Williams FMK","Lang T","Ralston SH","Cawthon PM","Diatchenko L"],"additional_accession":[]},"is_claimable":false,"name":"Disentangling the genetics of lean mass.","description":"<h4>Background</h4>Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass.<h4>Objectives</h4>To determine the impact of different fat mass adjustments on genetic architecture of LM and identify additional LM loci.<h4>Methods</h4>We performed genome-wide association analyses for whole-body LM (20 cohorts of European ancestry with n = 38,292) measured using dual-energy X-ray absorptiometry) or bioelectrical impedance analysis, adjusted for sex, age, age2, and height with or without fat mass adjustments (Model 1 no fat adjustment; Model 2 adjustment for fat m","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-04-08T06:13:37.385Z","creation":"2020-05-22T08:48:03Z"},"accession":"S-EPMC6500901","cross_references":{"pubmed":["30721968"],"doi":["10.1093/ajcn/nqy272"]}}