biostudies-literatureVicent-Gil MSpanish Ministry of Science and Innovation, Instituto Carlos III135https://www.ebi.ac.uk/biostudies/studies/S-EPMC6501398biostudies-literatureUnknown19(1)<h4>Background</h4>Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life.<h4>Methods</h4>A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCREBMC psychiatryTesting the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial.PMC6501398PI17/00056Gonzalez-Simarro SPerez-Blanco JTrujols JCardoner NRaventos BBonnin CDMde Diego-Adelino JPortella MJSerra-Blasco MVicent-Gil MPuigdemont DMartinez-Aran AMarin-Martinez EDfalseTesting the efficacy of INtegral Cognitive REMediation (INCREM) in major depressive disorder: study protocol for a randomized clinical trial.<h4>Background</h4>Given the limitation of pharmacological treatments to treat cognitive symptoms in patients with Major Depressive Disorder (MDD), cognitive remediation programs has been proposed as a possible procognitive intervention but findings are not conclusive. This study investigates the efficacy of an INtegral Cognitive REMediation (INCREM) that includes a combination of a Functional Remediation (FR) strategy plus a Computerized Cognitive Training (CCT) in order to improve not only cognitive performance but also the psychosocial functioning and the quality of life.<h4>Methods</h4>A single blind randomized controlled clinical trial in 81 patients with a diagnosis of MDD in clinical remission or in partial remission. Participants will be randomized to one of three conditions: INCRE2019-01-01T00:00:00Z2019 May2025-05-31T22:19:53.527Z2019-06-06T23:11:28ZS-EPMC65013983106060410.1186/s12888-019-2117-4