biostudies-literatureMarriott BPNational Institute on Alcohol Abuse and Alcoholism, NIHAker Biomarine Antarctic AS100359https://www.ebi.ac.uk/biostudies/studies/S-EPMC6503132biostudies-literatureUnknown15Intake of nutrients fundamental for optimal neuronal function is of increasing interest. The potential importance of omega-3 highly unsaturated fatty acids (HUFAs) for optimizing emotional states, cognitive function, and mental health has been demonstrated in observational studies and randomized controlled trials. Omega-3 (HUFAs), specifically EPA (eicosapentaenoic acid) and docosahexaenoic acid (DHA), are concentrated in neural tissues and are essential for neural function, normative neurodevelopment, neurotransmitter, and neural immune functions. Omega-3 HUFAs must be obtained from the diet, predominantly from marine sources such as fish and other seafood. HUFAs also can be found in a variety of dietary supplements (omega-3 fatty acid esters, fish oil and krill oil). As dietary supplemenContemporary clinical trials communicationsDesign and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study).PMC65031328B422-01Deveaux ADWissman JWSikon ALMalcolm RJBurbelo GAJohnson KBVelez Landivar AMNewman JMalek AMHibbeln JRTaylor CJNicholas LSTurner THMarriott BPRRIPP-3 GroupPregulman MAtkinson RARoss JSfalseDesign and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study).Intake of nutrients fundamental for optimal neuronal function is of increasing interest. The potential importance of omega-3 highly unsaturated fatty acids (HUFAs) for optimizing emotional states, cognitive function, and mental health has been demonstrated in observational studies and randomized controlled trials. Omega-3 (HUFAs), specifically EPA (eicosapentaenoic acid) and docosahexaenoic acid (DHA), are concentrated in neural tissues and are essential for neural function, normative neurodevelopment, neurotransmitter, and neural immune functions. Omega-3 HUFAs must be obtained from the diet, predominantly from marine sources such as fish and other seafood. HUFAs also can be found in a variety of dietary supplements (omega-3 fatty acid esters, fish oil and krill oil). As dietary supplemen2019-01-01T00:00:00Z2019 Sep2026-04-08T05:59:44.769Z2026-04-07T22:47:05.751ZS-EPMC65031323108090810.1016/j.conctc.2019.100359