{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Patel R"],"funding":["Oxford Percival Stanion Studentship","Medical Research Council","Biotechnology and Biological Sciences Research Council"],"pagination":["60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6507032"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<h4>Background</h4>Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a critical regulator of gene expression during disease. However, the effect of APA in the context of neurodegenerative diseases, to date, has not been widely investigated. Dynamic Analysis of Alternative Polyadenylation from RNA-seq (DaPars) is a method by Xia and colleagues [Nat Commun. 5:5274, 2014] to investigate APA using standard RNA-seq data. Here, we employed this method to interrogate APA using publicly available RNA-seq data from Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS) patients and "],"journal":["BMC medical genomics"],"pubmed_title":["Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS disease."],"pmcid":["PMC6507032"],"funding_grant_id":["NA","BB/N001184/1"],"pubmed_authors":["Neve J","Hickling M","Patel R","Brophy C","Furger A"],"additional_accession":[]},"is_claimable":false,"name":"Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS disease.","description":"<h4>Background</h4>Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a critical regulator of gene expression during disease. However, the effect of APA in the context of neurodegenerative diseases, to date, has not been widely investigated. Dynamic Analysis of Alternative Polyadenylation from RNA-seq (DaPars) is a method by Xia and colleagues [Nat Commun. 5:5274, 2014] to investigate APA using standard RNA-seq data. Here, we employed this method to interrogate APA using publicly available RNA-seq data from Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS) patients and ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2026-04-08T05:28:13.101Z","creation":"2019-06-06T23:02:05Z"},"accession":"S-EPMC6507032","cross_references":{"pubmed":["31072331"],"doi":["10.1186/s12920-019-0509-4"]}}