{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rosso M"],"funding":["Consejo Nacional de Investigaciones Científicas y Técnicas","Fundación Alberto J. Roemmers","FP7 People: Marie-Curie Actions","Instituto Nacional del Cáncer","Agencia Nacional de Promoción Científica y Tecnológica"],"pagination":["5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6507066"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["<h4>Background</h4>Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but the underlying molecular mechanisms have not been fully elucidated. We have previously reported a novel human E-cadherin splice variant (E-cadherin variant) mRNA. Stable transfectants in MCF-7 human BC cells (MCF7Ecadvar) depicted fibroblast-like cell morphology, E-cadherin wild-type downregulation, and other molecular changes characteristic of the epithelial-to-mesenchymal transition process, reduced cell-cell adhesion, and increased cell migration and invasion. In this study, a two-dimensional differential gel electrophoresis (2D-DIGE) combined with mass spectrome"],"journal":["Cancer & metabolism"],"pubmed_title":["Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B."],"pmcid":["PMC6507066"],"funding_grant_id":["2016-2017","PIP740","2011-2013","PICT SU 1072","2014-2015","PIP887","269285"],"pubmed_authors":["Matos ML","Besso MJ","Reventos J","Canals F","Quevedo Cuenca JO","Rosso M","Vazquez-Levin MH","Lapyckyj L","Monge M"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B.","description":"<h4>Background</h4>Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but the underlying molecular mechanisms have not been fully elucidated. We have previously reported a novel human E-cadherin splice variant (E-cadherin variant) mRNA. Stable transfectants in MCF-7 human BC cells (MCF7Ecadvar) depicted fibroblast-like cell morphology, E-cadherin wild-type downregulation, and other molecular changes characteristic of the epithelial-to-mesenchymal transition process, reduced cell-cell adhesion, and increased cell migration and invasion. In this study, a two-dimensional differential gel electrophoresis (2D-DIGE) combined with mass spectrome","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-07T02:14:56.396Z","creation":"2019-06-06T23:29:04Z"},"accession":"S-EPMC6507066","cross_references":{"pubmed":["31086659"],"doi":["10.1186/s40170-019-0196-9"]}}