{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Koller A"],"pubmed_abstract":["The regulatory peptide galanin is broadly distributed in the central- and peripheral nervous systems as well as in non-neuronal tissues, where it exerts its diverse physiological functions via three G-protein-coupled receptors (GAL<sub>1-3</sub>-R). Regulatory peptides are important mediators of the cross-communication between the nervous- and immune systems and have emerged as a focus of new therapeutics for a variety of inflammatory diseases. Studies on inflammatory animal models and immune cells revealed both pro- and anti-inflammatory functions of galanin. Here, we probed specific immune-related functions of the galanin system and found galanin and GAL<sub>1</sub>-R and GAL<sub>2</sub>-R mRNA to be expressed in a range of human immune cells. In particular, macrophages displayed differe"],"journal":["Scientific reports"],"pagination":["7237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6510899"],"repository":["biostudies-literature"],"pubmed_title":["Galanin is a potent modulator of cytokine and chemokine expression in human macrophages."],"pmcid":["PMC6510899"],"pubmed_authors":["Brunner SM","Emberger M","Sternberg F","Kofler B","Ramspacher A","Schlager S","Koller A","Bianchini R"],"additional_accession":[]},"is_claimable":false,"name":"Galanin is a potent modulator of cytokine and chemokine expression in human macrophages.","description":"The regulatory peptide galanin is broadly distributed in the central- and peripheral nervous systems as well as in non-neuronal tissues, where it exerts its diverse physiological functions via three G-protein-coupled receptors (GAL<sub>1-3</sub>-R). Regulatory peptides are important mediators of the cross-communication between the nervous- and immune systems and have emerged as a focus of new therapeutics for a variety of inflammatory diseases. Studies on inflammatory animal models and immune cells revealed both pro- and anti-inflammatory functions of galanin. Here, we probed specific immune-related functions of the galanin system and found galanin and GAL<sub>1</sub>-R and GAL<sub>2</sub>-R mRNA to be expressed in a range of human immune cells. In particular, macrophages displayed differe","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-29T11:12:52.177Z","creation":"2019-06-06T23:13:36Z"},"accession":"S-EPMC6510899","cross_references":{"pubmed":["31076613"],"doi":["10.1038/s41598-019-43704-7"]}}