biostudies-literatureMartinez-Antonio EMCONACYTDACI-Conacyte6850https://www.ebi.ac.uk/biostudies/studies/S-EPMC6511226biostudies-literatureUnknown7The high tolerance of Litopenaeus vannamei to a wide range of salinity (1-50 psu) makes this species an excellent candidate for culture under low salinity, decreasing shrimp epidemics and water pollution in some coastal areas. However, salinity levels outside the optimal range could impose several physiological constraints that would in turn affect growth and survival, particularly in the presence of additional stressors (e.g. high densities, handling practices, and hypoxia). Despite shrimp susceptibility to individual stressors has been widely addressed, information regarding response to chronic and acute stressors combined and its relation to diet is scarce. Thus, the aim of our study was to determine the effect of diet on the susceptibility to chronic (low salinity) and acute (hypoxia aPeerJModulation of stress response and productive performance of Litopenaeus vannamei through diet.PMC6511226grant number 260464296397Magallon-Barajas FRuvalcaba-Marquez JCRacotta ISMartinez-Antonio EMfalseModulation of stress response and productive performance of Litopenaeus vannamei through diet.The high tolerance of Litopenaeus vannamei to a wide range of salinity (1-50 psu) makes this species an excellent candidate for culture under low salinity, decreasing shrimp epidemics and water pollution in some coastal areas. However, salinity levels outside the optimal range could impose several physiological constraints that would in turn affect growth and survival, particularly in the presence of additional stressors (e.g. high densities, handling practices, and hypoxia). Despite shrimp susceptibility to individual stressors has been widely addressed, information regarding response to chronic and acute stressors combined and its relation to diet is scarce. Thus, the aim of our study was to determine the effect of diet on the susceptibility to chronic (low salinity) and acute (hypoxia a2019-01-01T00:00:00Z20192025-05-29T20:21:47.78Z2025-05-29T20:21:47.78ZS-EPMC65112263111907510.7717/peerj.6850