{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McGregor NE"],"funding":["Department of Education and Training","Department of Health | National Health and Medical Research Council"],"pagination":["7850-7863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6514630"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["294(19)"],"pubmed_abstract":["Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bound (<i>cis</i>) or soluble (<i>trans</i>) receptors. Here, we investigated how IL-6 signals and modifies gene expression in differentiated osteoblasts and osteocytes and determined whether these activities can promote bone formation or support osteoclastogenesis. Moreover, we used a genetically altered mouse with circulating levels of the pharmacological IL-6 <i>trans</i>-signaling inhibitor sgp130-Fc to determine whether IL-6 <i>trans</i>-signaling is required for normal bone growth and remodeling. We found that IL-6 increases suppressor of cytokine signaling 3 (<i>Socs3</i>) and CCAAT enhancer-binding protein δ (<i>Cebpd</i>) mRNA levels and promotes signal tr"],"journal":["The Journal of biological chemistry"],"pubmed_title":["IL-6 exhibits both <i>cis</i>- and <i>trans</i>-signaling in osteocytes and osteoblasts, but only <i>trans</i>-signaling promotes bone formation and osteoclastogenesis."],"pmcid":["PMC6514630"],"funding_grant_id":["Project Grant 1081242","Senior Research Fellowships 1019703 and 1154819","Endeavour Fellowship"],"pubmed_authors":["Elango J","Murat M","Martin TJ","Sims NA","Crimeen-Irwin B","Ho PWM","Walker EC","McGregor NE","Gooi JH","Poulton IJ"],"additional_accession":[]},"is_claimable":false,"name":"IL-6 exhibits both <i>cis</i>- and <i>trans</i>-signaling in osteocytes and osteoblasts, but only <i>trans</i>-signaling promotes bone formation and osteoclastogenesis.","description":"Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bound (<i>cis</i>) or soluble (<i>trans</i>) receptors. Here, we investigated how IL-6 signals and modifies gene expression in differentiated osteoblasts and osteocytes and determined whether these activities can promote bone formation or support osteoclastogenesis. Moreover, we used a genetically altered mouse with circulating levels of the pharmacological IL-6 <i>trans</i>-signaling inhibitor sgp130-Fc to determine whether IL-6 <i>trans</i>-signaling is required for normal bone growth and remodeling. We found that IL-6 increases suppressor of cytokine signaling 3 (<i>Socs3</i>) and CCAAT enhancer-binding protein δ (<i>Cebpd</i>) mRNA levels and promotes signal tr","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-04T07:57:48.113Z","creation":"2025-04-04T07:57:48.113Z"},"accession":"S-EPMC6514630","cross_references":{"pubmed":["30923130"],"doi":["10.1074/jbc.ra119.008074","10.1074/jbc.RA119.008074"]}}