{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang YY"],"funding":["Development and Regeneration Key Laboratory of Sichuan Province","National Natural Science Foundation of China"],"pagination":["714-733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6515707"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(6)"],"pubmed_abstract":["Aims
The G-protein-coupled estrogen receptor GPR30 (also referred to as GPER) has been implicated in the estrogenic regulation of hippocampal plasticity and spatial memory; however, the molecular mechanisms are largely unclear.Methods
In this study, we initially examined the levels of GPR30 in the hippocampus of postnatal, ovariectomy (OVX)- and letrozole (LET)-treated female mice. Under G1, G15, and/or OVX treatment, the spatial memory, spine density, levels of ERα, ERβ, and SRC-1, selected synaptic proteins, mTORC2 signals (Rictor and p-AKT Ser473), and actin polymerization dynamics were subsequently evaluated. Furthermore, G1, G15, and/or E2 combined with SRC-1 and/or PI3K inhibitors, actin cytoskeleton polymerization modulator JPK, and CytoD treatments were used to addr"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["GPR30-mediated estrogenic regulation of actin polymerization and spatial memory involves SRC-1 and PI3K-mTORC2 in the hippocampus of female mice."],"pmcid":["PMC6515707"],"funding_grant_id":["SYS15001","81571059"],"pubmed_authors":["Zhao YG","Li W","Zhang YY","Liu Z","Zhao JK","Liu MY","He L","Zhang JQ"],"additional_accession":[]},"is_claimable":false,"name":"GPR30-mediated estrogenic regulation of actin polymerization and spatial memory involves SRC-1 and PI3K-mTORC2 in the hippocampus of female mice.","description":"Aims
The G-protein-coupled estrogen receptor GPR30 (also referred to as GPER) has been implicated in the estrogenic regulation of hippocampal plasticity and spatial memory; however, the molecular mechanisms are largely unclear.Methods
In this study, we initially examined the levels of GPR30 in the hippocampus of postnatal, ovariectomy (OVX)- and letrozole (LET)-treated female mice. Under G1, G15, and/or OVX treatment, the spatial memory, spine density, levels of ERα, ERβ, and SRC-1, selected synaptic proteins, mTORC2 signals (Rictor and p-AKT Ser473), and actin polymerization dynamics were subsequently evaluated. Furthermore, G1, G15, and/or E2 combined with SRC-1 and/or PI3K inhibitors, actin cytoskeleton polymerization modulator JPK, and CytoD treatments were used to addr","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-05T13:02:33.956Z","creation":"2019-07-25T07:16:16Z"},"accession":"S-EPMC6515707","cross_references":{"pubmed":["30714337"],"doi":["10.1111/cns.13108"]}}