biostudies-literatureYin XNobel Biocare Services AGChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaNational Institutes of HealthE427https://www.ebi.ac.uk/biostudies/studies/S-EPMC6517945biostudies-literatureUnknown8(4)Of all geometric shapes, a tri-oval one may be the strongest because of its capacity to bear large loads with neither rotation nor deformation. Here, we modified the external shape of a dental implant from circular to tri-oval, aiming to create a combination of high strain and low strain peri-implant environment that would ensure both primary implant stability and rapid osseointegration, respectively. Using in vivo mouse models, we tested the effects of this geometric alteration on implant survival and osseointegration over time. The maxima regions of tri-oval implants provided superior primary stability without increasing insertion torque. The minima regions of tri-oval implants presented low compressive strain and significantly less osteocyte apoptosis, which led to minimal bone resorptiJournal of clinical medicineMechanical and Biological Advantages of a Tri-Oval Implant Design.PMC65179452018M640929818010192015-1400DE 024000Hoffmann WBrunski JBYin XLi JHelms JAGasser AfalseMechanical and Biological Advantages of a Tri-Oval Implant Design.Of all geometric shapes, a tri-oval one may be the strongest because of its capacity to bear large loads with neither rotation nor deformation. Here, we modified the external shape of a dental implant from circular to tri-oval, aiming to create a combination of high strain and low strain peri-implant environment that would ensure both primary implant stability and rapid osseointegration, respectively. Using in vivo mouse models, we tested the effects of this geometric alteration on implant survival and osseointegration over time. The maxima regions of tri-oval implants provided superior primary stability without increasing insertion torque. The minima regions of tri-oval implants presented low compressive strain and significantly less osteocyte apoptosis, which led to minimal bone resorpti2019-01-01T00:00:00Z2019 Mar2025-04-26T19:19:27.157Z2019-07-01T13:51:49ZS-EPMC65179453092574610.3390/jcm8040427