biostudies-literatureBurkhouse KLKlingenstein Third Generation FoundationNCATS NIH HHSNIMH NIH HHSNational Institute of Mental HealthMind and Life Foundation141-152https://www.ebi.ac.uk/biostudies/studies/S-EPMC6519436biostudies-literatureUnknown36(2)<h4>Background</h4>Three well-established intrinsic connectivity networks (ICNs) involved in cognitive-affective processing include the cognitive control network (CCN), default mode network (DMN), and salience and emotional network (SEN). Despite recent advances in understanding developmental changes in these ICNs, the majority of research has focused on single seeds or networks in isolation with limited age ranges. Additionally, although internalizing psychopathologies (IPs), such as anxiety and depression, are often characterized by maladaptive cognitive-affective processing styles, it is not clear how IP history influences age-related changes in brain networks.<h4>Method</h4>The current study aimed to characterize the normative development of the CCN, DMN, and SEN across a large age-spaDepression and anxietyDevelopmental changes in resting-state functional networks among individuals with and without internalizing psychopathologies.PMC6519436MH112769R01 MH086517K23 MH113793UL1 TR002003MH101487R01 MH101487MH091811MH113793MH086517L30 MH114407R01 MH091811UL1 TR000050T32 MH067631K23 MH112769Jacobs RHPeters ATKreutzer KAPhan KLBessette KLBurkhouse KLBhaumik RWelsh RCStange JPMonk CSLangenecker SAFitzgerald KCrane NAfalseDevelopmental changes in resting-state functional networks among individuals with and without internalizing psychopathologies.<h4>Background</h4>Three well-established intrinsic connectivity networks (ICNs) involved in cognitive-affective processing include the cognitive control network (CCN), default mode network (DMN), and salience and emotional network (SEN). Despite recent advances in understanding developmental changes in these ICNs, the majority of research has focused on single seeds or networks in isolation with limited age ranges. Additionally, although internalizing psychopathologies (IPs), such as anxiety and depression, are often characterized by maladaptive cognitive-affective processing styles, it is not clear how IP history influences age-related changes in brain networks.<h4>Method</h4>The current study aimed to characterize the normative development of the CCN, DMN, and SEN across a large age-spa2019-01-01T00:00:00Z2019 Feb2026-07-14T14:31:18.547Z2019-06-06T23:02:38ZS-EPMC65194363051685310.1002/da.22864