{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song D"],"funding":["Young Scientists Fund"],"pagination":["158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6521571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Telocytes play key roles in maintenance of organ/tissue function and prevention of organ injury. However, there are great challenges to investigate telocytes functions using primary telocytes, due to the difficulties of isolation, identification, and stability. The present study aims at constructing continuous cell strain of mouse lung telocyte cell line with stable characters by gene modification and investigating biological behaviors and responses of gene-modified telocytes to inflammation.<h4>Methods</h4>Mouse primary lung telocytes were isolated and identified using immune-labeling markers and immunoelectron microscopy. Primary telocytes were transformed with Simian vacuolating virus 40 small and large T antigen (SV40). Biological characters, behaviors morphology, an"],"journal":["Journal of translational medicine"],"pubmed_title":["Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation."],"pmcid":["PMC6521571"],"funding_grant_id":["81700008"],"pubmed_authors":["Fang H","Ma R","Xu M","Song D","Wu D","Wang X","Qi R","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation.","description":"<h4>Background</h4>Telocytes play key roles in maintenance of organ/tissue function and prevention of organ injury. However, there are great challenges to investigate telocytes functions using primary telocytes, due to the difficulties of isolation, identification, and stability. The present study aims at constructing continuous cell strain of mouse lung telocyte cell line with stable characters by gene modification and investigating biological behaviors and responses of gene-modified telocytes to inflammation.<h4>Methods</h4>Mouse primary lung telocytes were isolated and identified using immune-labeling markers and immunoelectron microscopy. Primary telocytes were transformed with Simian vacuolating virus 40 small and large T antigen (SV40). Biological characters, behaviors morphology, an","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-04T18:35:49.926Z","creation":"2019-06-06T23:16:14Z"},"accession":"S-EPMC6521571","cross_references":{"pubmed":["31092264"],"doi":["10.1186/s12967-019-1870-y"]}}