{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kaasch AJ"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","Paul-Ehrlich Gesellschaft für Chemotherapie"],"pagination":["ofz170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6521783"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(5)"],"pubmed_abstract":["<h4>Background</h4>The standard treatment duration in low-risk <i>Staphylococcus aureus</i> bloodstream (SAB) is 14 days. However, it is unclear whether an extended course of antimicrobial therapy is necessary in patients with clinically uninfected prosthetic joints/osteosyntheses or pacemakers/automated implanted cardioverter-defibrillators (AICDs). Thus, we compared the duration of antimicrobial therapy and outcomes in patients with and those without clinically uninfected foreign bodies.<h4>Methods</h4>We conducted a post hoc analysis of data from the prospective Invasive <i>Staphylococcus aureus</i> Infection Cohort (INSTINCT) study. Adult low-risk patients who survived ≥4 days were assessed for duration of treatment, SAB-related events (attributable death, relapse, or new deep-seated i"],"journal":["Open forum infectious diseases"],"pubmed_title":["Effect of Clinically Uninfected Orthopedic Implants and Pacemakers/AICDs in Low-Risk <i>Staphylococcus aureus</i> Bloodstream Infection on Crude Mortality Rate: A Post Hoc Analysis of a Large Cohort Study."],"pmcid":["PMC6521783"],"funding_grant_id":["BMBF","01KI1017","01KN1106","KA 3104/1-1"],"pubmed_authors":["Hellmich M","Kaasch AJ","Seifert H","Rieg S","Kern WV","Joost I"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Clinically Uninfected Orthopedic Implants and Pacemakers/AICDs in Low-Risk <i>Staphylococcus aureus</i> Bloodstream Infection on Crude Mortality Rate: A Post Hoc Analysis of a Large Cohort Study.","description":"<h4>Background</h4>The standard treatment duration in low-risk <i>Staphylococcus aureus</i> bloodstream (SAB) is 14 days. However, it is unclear whether an extended course of antimicrobial therapy is necessary in patients with clinically uninfected prosthetic joints/osteosyntheses or pacemakers/automated implanted cardioverter-defibrillators (AICDs). Thus, we compared the duration of antimicrobial therapy and outcomes in patients with and those without clinically uninfected foreign bodies.<h4>Methods</h4>We conducted a post hoc analysis of data from the prospective Invasive <i>Staphylococcus aureus</i> Infection Cohort (INSTINCT) study. Adult low-risk patients who survived ≥4 days were assessed for duration of treatment, SAB-related events (attributable death, relapse, or new deep-seated i","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2026-05-01T04:56:29.773Z","creation":"2019-06-06T23:16:16Z"},"accession":"S-EPMC6521783","cross_references":{"pubmed":["31111077"],"doi":["10.1093/ofid/ofz170"]}}