biostudies-literatureKaasch AJBundesministerium für Bildung und ForschungDeutsche ForschungsgemeinschaftPaul-Ehrlich Gesellschaft für Chemotherapieofz170https://www.ebi.ac.uk/biostudies/studies/S-EPMC6521783biostudies-literatureUnknown6(5)<h4>Background</h4>The standard treatment duration in low-risk <i>Staphylococcus aureus</i> bloodstream (SAB) is 14 days. However, it is unclear whether an extended course of antimicrobial therapy is necessary in patients with clinically uninfected prosthetic joints/osteosyntheses or pacemakers/automated implanted cardioverter-defibrillators (AICDs). Thus, we compared the duration of antimicrobial therapy and outcomes in patients with and those without clinically uninfected foreign bodies.<h4>Methods</h4>We conducted a post hoc analysis of data from the prospective Invasive <i>Staphylococcus aureus</i> Infection Cohort (INSTINCT) study. Adult low-risk patients who survived ≥4 days were assessed for duration of treatment, SAB-related events (attributable death, relapse, or new deep-seated iOpen forum infectious diseasesEffect of Clinically Uninfected Orthopedic Implants and Pacemakers/AICDs in Low-Risk <i>Staphylococcus aureus</i> Bloodstream Infection on Crude Mortality Rate: A Post Hoc Analysis of a Large Cohort Study.PMC6521783BMBF01KI101701KN1106KA 3104/1-1Hellmich MKaasch AJSeifert HRieg SKern WVJoost IfalseEffect of Clinically Uninfected Orthopedic Implants and Pacemakers/AICDs in Low-Risk <i>Staphylococcus aureus</i> Bloodstream Infection on Crude Mortality Rate: A Post Hoc Analysis of a Large Cohort Study.<h4>Background</h4>The standard treatment duration in low-risk <i>Staphylococcus aureus</i> bloodstream (SAB) is 14 days. However, it is unclear whether an extended course of antimicrobial therapy is necessary in patients with clinically uninfected prosthetic joints/osteosyntheses or pacemakers/automated implanted cardioverter-defibrillators (AICDs). Thus, we compared the duration of antimicrobial therapy and outcomes in patients with and those without clinically uninfected foreign bodies.<h4>Methods</h4>We conducted a post hoc analysis of data from the prospective Invasive <i>Staphylococcus aureus</i> Infection Cohort (INSTINCT) study. Adult low-risk patients who survived ≥4 days were assessed for duration of treatment, SAB-related events (attributable death, relapse, or new deep-seated i2019-01-01T00:00:00Z2019 May2026-05-01T04:56:29.773Z2019-06-06T23:16:16ZS-EPMC65217833111107710.1093/ofid/ofz170