{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paek AR"],"funding":["National Cancer Center","National Research Foundation of Korea","Korea Brain Research Institute"],"pagination":["E296"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6523662"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(4)"],"pubmed_abstract":["Autophagy is a cellular process that disrupts and uses unnecessary or malfunctioning components for cellular homeostasis. Evidence has shown a role for autophagy in tumor cell survival, but the molecular determinants that define sensitivity against autophagic regulation in cancers are not clear. Importantly, we found that breast cancer cells with low expression levels of a zinc-finger protein, ZNF143 (MCF7 sh-ZNF143), showed better survival than control cells (MCF7 sh-Control) under starvation, which was compromised with chloroquine, an autophagy inhibitor. In addition, there were more autophagic vesicles in MCF7 sh-ZNF143 cells than in MCF7 sh-Control cells, and proteins related with the autophagic process, such as Beclin1, p62, and ATGs, were altered in cells with less ZNF143. ZNF143 kno"],"journal":["Cells"],"pubmed_title":["The Role of ZNF143 in Breast Cancer Cell Survival Through the NAD(P)H Quinone Dehydrogenase 1⁻p53⁻Beclin1 Axis Under Metabolic Stress."],"pmcid":["PMC6523662"],"funding_grant_id":["2015R1A2A2A01003829","NCC-1710180","ICT(19-BR-01-08)"],"pubmed_authors":["Cheong H","Mun JY","You HJ","Paek AR","Park J","Choi H","Lee YJ","Hong DW","Kim KH","Jo MJ","Myung JK"],"additional_accession":[]},"is_claimable":false,"name":"The Role of ZNF143 in Breast Cancer Cell Survival Through the NAD(P)H Quinone Dehydrogenase 1⁻p53⁻Beclin1 Axis Under Metabolic Stress.","description":"Autophagy is a cellular process that disrupts and uses unnecessary or malfunctioning components for cellular homeostasis. Evidence has shown a role for autophagy in tumor cell survival, but the molecular determinants that define sensitivity against autophagic regulation in cancers are not clear. Importantly, we found that breast cancer cells with low expression levels of a zinc-finger protein, ZNF143 (MCF7 sh-ZNF143), showed better survival than control cells (MCF7 sh-Control) under starvation, which was compromised with chloroquine, an autophagy inhibitor. In addition, there were more autophagic vesicles in MCF7 sh-ZNF143 cells than in MCF7 sh-Control cells, and proteins related with the autophagic process, such as Beclin1, p62, and ATGs, were altered in cells with less ZNF143. ZNF143 kno","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-05T10:43:52.098Z","creation":"2019-07-01T13:53:06Z"},"accession":"S-EPMC6523662","cross_references":{"pubmed":["30935019"],"doi":["10.3390/cells8040296"]}}