{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dolan MJ"],"funding":["Herchel Smith Scholarship","European Research Council","Howard Hughes Medical Institute","Medical Research Council","Wellcome Trust","Boehringer Ingelheim Fonds"],"pagination":["e43079"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6529221"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In <i>Drosophila</i>, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic tools for this region. We generate a collection of split-GAL4 driver lines providing genetic access to 82 LH cell types. We use these to create an anatomical and neurotransmitter map of the LH and link this to EM connectomics data. We find ~30% of LH projections converge with outputs from the mushroom body, site of olfactory learning and memory. Using optogenetic activation, we identify LH cell types that drive changes in valence behavior or specific locomotor programs. "],"journal":["eLife"],"pubmed_title":["Neurogenetic dissection of the <i>Drosophila</i> lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body."],"pmcid":["PMC6529221"],"funding_grant_id":["203261/Z/16/Z","211089","MC_U105188491","PhD Fellowship","MC-U105188491","Starting grant 211089","Consolidator grant 649111","MC_U105184326","649111","Janelia Graduate Research Fellowship","LMB Graduate Studentships"],"pubmed_authors":["Dhawan S","Bock DD","Ihrke G","Li F","Meissner GW","Dionne H","Rubin GM","Frechter S","Bates AS","Sutcliffe B","Jefferis GS","Christoforou C","Dolan MJ","Huoviala P","Costa M","Schlegel P","Tabano R","Roberts RJ","Close K","Dan C","Giuliani B","Aso Y"],"additional_accession":[]},"is_claimable":false,"name":"Neurogenetic dissection of the <i>Drosophila</i> lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.","description":"Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In <i>Drosophila</i>, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic tools for this region. We generate a collection of split-GAL4 driver lines providing genetic access to 82 LH cell types. We use these to create an anatomical and neurotransmitter map of the LH and link this to EM connectomics data. We find ~30% of LH projections converge with outputs from the mushroom body, site of olfactory learning and memory. Using optogenetic activation, we identify LH cell types that drive changes in valence behavior or specific locomotor programs. ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-18T18:49:45.007Z","creation":"2019-06-06T23:18:14Z"},"accession":"S-EPMC6529221","cross_references":{"pubmed":["31112130"],"doi":["10.7554/eLife.43079"]}}