{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schmidt ME"],"funding":["NIAID NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["3234-3245"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6529240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["202(11)"],"pubmed_abstract":["Respiratory syncytial virus (RSV) is the leading cause of severe respiratory tract infection in infants and young children, but no vaccine is currently available. Live-attenuated vaccines represent an attractive immunization approach; however, balancing attenuation while retaining sufficient immunogenicity and efficacy has prevented the successful development of such a vaccine. Recently, a recombinant RSV strain lacking the gene that encodes the matrix (M) protein (RSV M-null) was developed. The M protein is required for virion assembly following infection of a host cell but is not necessary for either genome replication or gene expression. Therefore, infection with RSV M-null produces all viral proteins except M but does not generate infectious virus progeny, resulting in a single-cycle i"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice."],"pmcid":["PMC6529240"],"funding_grant_id":["P20 GM103648","R01 AI124093","T32 AI007485","P30 CA086862"],"pubmed_authors":["Oomens AGP","Varga SM","Schmidt ME"],"additional_accession":[]},"is_claimable":false,"name":"Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice.","description":"Respiratory syncytial virus (RSV) is the leading cause of severe respiratory tract infection in infants and young children, but no vaccine is currently available. Live-attenuated vaccines represent an attractive immunization approach; however, balancing attenuation while retaining sufficient immunogenicity and efficacy has prevented the successful development of such a vaccine. Recently, a recombinant RSV strain lacking the gene that encodes the matrix (M) protein (RSV M-null) was developed. The M protein is required for virion assembly following infection of a host cell but is not necessary for either genome replication or gene expression. Therefore, infection with RSV M-null produces all viral proteins except M but does not generate infectious virus progeny, resulting in a single-cycle i","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-04T14:00:25.157Z","creation":"2020-06-04T07:05:09Z"},"accession":"S-EPMC6529240","cross_references":{"pubmed":["31004010"],"doi":["10.4049/jimmunol.1900050"]}}