{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Tahrioui A"],"pubmed_abstract":["Biofilms are structured microbial communities that are the leading cause of numerous chronic infections which are difficult to eradicate. Within the lungs of individuals with cystic fibrosis (CF), <i>Pseudomonas aeruginosa</i> causes persistent biofilm infection that is commonly treated with aminoglycoside antibiotics such as tobramycin. However, sublethal concentrations of this aminoglycoside were previously shown to increase biofilm formation by <i>P. aeruginosa</i>, but the underlying adaptive mechanisms still remain elusive. Herein, we combined confocal laser scanning microscope analyses, proteomics profiling, gene expression assays and phenotypic studies to unravel <i>P. aeruginosa</i> potential adaptive mechanisms in response to tobramycin exposure during biofilm growth. Under this c"],"journal":["NPJ biofilms and microbiomes"],"pagination":["15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6533273"],"repository":["biostudies-literature"],"pubmed_title":["Extracellular DNA release, quorum sensing, and PrrF1/F2 small RNAs are key players in <i>Pseudomonas aeruginosa</i> tobramycin-enhanced biofilm formation."],"pmcid":["PMC6533273"],"pubmed_authors":["Rodrigues S","Bouffartigues E","Groleau MC","Lesouhaitier O","Brenner-Weiss G","Feuilloley M","Duchesne R","Tortuel D","Maillot O","Dufour A","Chevalier S","Tahrioui A","Hardouin J","Deziel E","Taupin L","Orange N","Cornelis P"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular DNA release, quorum sensing, and PrrF1/F2 small RNAs are key players in <i>Pseudomonas aeruginosa</i> tobramycin-enhanced biofilm formation.","description":"Biofilms are structured microbial communities that are the leading cause of numerous chronic infections which are difficult to eradicate. Within the lungs of individuals with cystic fibrosis (CF), <i>Pseudomonas aeruginosa</i> causes persistent biofilm infection that is commonly treated with aminoglycoside antibiotics such as tobramycin. However, sublethal concentrations of this aminoglycoside were previously shown to increase biofilm formation by <i>P. aeruginosa</i>, but the underlying adaptive mechanisms still remain elusive. Herein, we combined confocal laser scanning microscope analyses, proteomics profiling, gene expression assays and phenotypic studies to unravel <i>P. aeruginosa</i> potential adaptive mechanisms in response to tobramycin exposure during biofilm growth. Under this c","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-04T21:40:24.554Z","creation":"2019-07-01T13:54:51Z"},"accession":"S-EPMC6533273","cross_references":{"pubmed":["31149345"],"doi":["10.1038/s41522-019-0088-3"]}}