{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Doom JR"],"funding":["NICHD NIH HHS","NHLBI NIH HHS","National Institutes of Health"],"pagination":["85-91.e1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6535359"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["209"],"pubmed_abstract":["OBJECTIVE:To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence. STUDY DESIGN:Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight ≥3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence. RESULTS:Adolescents ranged from 16 to 18 years of age (n = 588; 48.1% female). A poorer infant psychosocial environment was associated with BMI z score at 10 years (β = 0.10, 95% CI = 0.00-0.19) and in adolescence (β = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infant psychosocial environment was associated with higher blood pressure (β = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (β = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (β = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.06-2.12). CONCLUSIONS:These findings demonstrate that a poorer infant psychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants' psychosocial environments and further research into causality, mechanisms, prevention, and intervention."],"journal":["The Journal of pediatrics"],"pubmed_title":["Infant Psychosocial Environment Predicts Adolescent Cardiometabolic Risk: A Prospective Study."],"pmcid":["PMC6535359"],"funding_grant_id":["R01HD33487","F32 HD088029","F32HD088029","R01HD14122","R01 HL088530","R01HL088530","R01 HD033487"],"pubmed_authors":["Doom JR","Gahagan S","Lozoff B","Reid BM","Blanco E","Burrows R"],"additional_accession":[]},"is_claimable":false,"name":"Infant Psychosocial Environment Predicts Adolescent Cardiometabolic Risk: A Prospective Study.","description":"OBJECTIVE:To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence. STUDY DESIGN:Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight ≥3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence. RESULTS:Adolescents ranged from 16 to 18 years of age (n = 588; 48.1% female). A poorer infant psychosocial environment was associated with BMI z score at 10 years (β = 0.10, 95% CI = 0.00-0.19) and in adolescence (β = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infant psychosocial environment was associated with higher blood pressure (β = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (β = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (β = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.06-2.12). CONCLUSIONS:These findings demonstrate that a poorer infant psychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants' psychosocial environments and further research into causality, mechanisms, prevention, and intervention.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2024-02-15T08:38:59.005Z","creation":"2020-06-04T07:05:48Z"},"accession":"S-EPMC6535359","cross_references":{"pubmed":["30876752"],"doi":["10.1016/j.jpeds.2019.01.058"]}}