biostudies-literatureZeininger LDeutsche ForschungsgemeinschaftU.S. Department of AgricultureArmy Research OfficeDivision of Materials ResearchNational Institute of General Medical SciencesNIGMS NIH HHS789-795https://www.ebi.ac.uk/biostudies/studies/S-EPMC6535765biostudies-literatureUnknown5(5)Reliable early-stage detection of foodborne pathogens is a global public health challenge that requires new and improved sensing strategies. Here, we demonstrate that dynamically reconfigurable fluorescent double emulsions can function as highly responsive optical sensors for the rapid detection of carbohydrates fructose, glucose, mannose, and mannan, which are involved in many biological and pathogenic phenomena. The proposed detection strategy relies on reversible reactions between boronic acid surfactants and carbohydrates at the hydrocarbon/water interface leading to a dynamic reconfiguration of the droplet morphology, which alters the angular distribution of the droplet's fluorescent light emission. We exploit this unique chemical-morphological-optical coupling to detect <i>SalmonellaACS central scienceRapid Detection of <i>Salmonella enterica</i> via Directional Emission from Carbohydrate-Functionalized Dynamic Double Emulsions.PMC6535765DMREF-1533985R01 GM0958438072-42000-084ZE1121/1-1GM095843W911NF-18-2-0048Savagatrup SNagelberg SZeininger LYoshinaga KCapobianco JAHarvey KSSwager TMHerbert MBKolle MfalseRapid Detection of <i>Salmonella enterica</i> via Directional Emission from Carbohydrate-Functionalized Dynamic Double Emulsions.Reliable early-stage detection of foodborne pathogens is a global public health challenge that requires new and improved sensing strategies. Here, we demonstrate that dynamically reconfigurable fluorescent double emulsions can function as highly responsive optical sensors for the rapid detection of carbohydrates fructose, glucose, mannose, and mannan, which are involved in many biological and pathogenic phenomena. The proposed detection strategy relies on reversible reactions between boronic acid surfactants and carbohydrates at the hydrocarbon/water interface leading to a dynamic reconfiguration of the droplet morphology, which alters the angular distribution of the droplet's fluorescent light emission. We exploit this unique chemical-morphological-optical coupling to detect <i>Salmonella2019-01-01T00:00:00Z2019 May2025-04-04T10:14:41.317Z2019-06-06T23:19:27ZS-EPMC65357653113971510.1021/acscentsci.9b00059