biostudies-literatureUnknown2019Randriamboavonjy JIRégion Pays de la LoireVascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial NO^· bioavailability and elevated vasoconstrictor and inflammatory mediator production, vascular rigidity, and tone impairment. <i>Moringa oleifera</i> (MOI) is a little tree, and different parts of which are used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including cardiovascular disease. The present study is aimed at assessing the effect of MOI on aging-associated alteration of the endothelial function in Wistar rats. Middle-aged Wistar rats (46-week-old males) have been fed with food containing or not 750 mg/kg/day of MOI seed powder for 4 weeks. A group of youOxidative medicine and cellular longevity2567198https://www.ebi.ac.uk/biostudies/studies/S-EPMC6535829biostudies-literature<i>Moringa oleifera</i> Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats.PMC6535829Heurtebise SLoirand GPacaud PTesse ARandriamboavonjy JIfalse<i>Moringa oleifera</i> Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats.Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial NO^· bioavailability and elevated vasoconstrictor and inflammatory mediator production, vascular rigidity, and tone impairment. <i>Moringa oleifera</i> (MOI) is a little tree, and different parts of which are used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including cardiovascular disease. The present study is aimed at assessing the effect of MOI on aging-associated alteration of the endothelial function in Wistar rats. Middle-aged Wistar rats (46-week-old males) have been fed with food containing or not 750 mg/kg/day of MOI seed powder for 4 weeks. A group of you2019-01-01T00:00:00Z20192025-04-04T10:15:03.353Z2019-07-24T07:04:56ZS-EPMC65358293121427810.1155/2019/2567198