{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Smoak MM"],"funding":["NIDCR NIH HHS","NIBIB NIH HHS"],"pagination":["276-287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6535957"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(5)"],"pubmed_abstract":["Although skeletal muscle has a high potential for self-repair, volumetric muscle loss can result in impairment beyond the endogenous regenerative capacity. There is a clinical need to improve on current clinical treatments that fail to fully restore the structure and function of lost muscle. Decellularized extracellular matrix (dECM) scaffolds have been an attractive platform for regenerating skeletal muscle, as dECM contains many biochemical cues that aid in cell adhesion, proliferation, and differentiation. However, there is limited capacity to tune physicochemical properties in current dECM technologies to improve outcome. In this study, we aim to create a novel, high-throughput technique to fabricate dECM scaffolds with tunable physicochemical properties while retaining proregenerative"],"journal":["Tissue engineering. Part C, Methods"],"pubmed_title":["Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds."],"pmcid":["PMC6535957"],"funding_grant_id":["P41 EB023833","F31 DE027586"],"pubmed_authors":["Watson E","Han A","Grande-Allen KJ","Mikos AG","Cosgriff-Hernandez E","Kishan A","Smoak MM"],"additional_accession":[]},"is_claimable":false,"name":"Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds.","description":"Although skeletal muscle has a high potential for self-repair, volumetric muscle loss can result in impairment beyond the endogenous regenerative capacity. There is a clinical need to improve on current clinical treatments that fail to fully restore the structure and function of lost muscle. Decellularized extracellular matrix (dECM) scaffolds have been an attractive platform for regenerating skeletal muscle, as dECM contains many biochemical cues that aid in cell adhesion, proliferation, and differentiation. However, there is limited capacity to tune physicochemical properties in current dECM technologies to improve outcome. In this study, we aim to create a novel, high-throughput technique to fabricate dECM scaffolds with tunable physicochemical properties while retaining proregenerative","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-21T16:03:45.325Z","creation":"2025-04-21T16:03:45.325Z"},"accession":"S-EPMC6535957","cross_references":{"pubmed":["30909819"],"doi":["10.1089/ten.TEC.2018.0339","10.1089/ten.tec.2018.0339"]}}