biostudies-literatureGrant DJNational Institute of Environmental Health SciencesNational Center for Advancing Translational SciencesCancer Research UKNCATS NIH HHSNIEHS NIH HHSOvarian Cancer Research FundCanadian Institutes of Health ResearchPrincess Margaret Cancer FoundationAmerican Cancer SocietyNIMHD NIH HHSCancer Institute NSWNational Institute for Health Research (NIHR)NCI NIH HHSNIH HHS2503-2513https://www.ebi.ac.uk/biostudies/studies/S-EPMC6536963biostudies-literatureUnknown8(5)An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significancCancer medicineEvaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.PMC6536963U54 CA156735P30 CA008748K07 CA080668P50 CA159981P01 CA087969UL1 TR001881R03 CA113148R01 CA160669P30 CA071789R01 CA12244310119P50 CA105009R01 CA114343P30 CA076292R01 CA11252316561S10 OD025170R03 CA115195UL1 TR00012422905Z01 ES049033C490/A10124R01 CA126841UM1 CA176726C490/A10119N01 CN025403P50 CA136393R01 CA058860U19 CA148112U54 MD012393Z01 ES044005UM1 CA186107R01 CA142081Taylor JAO'Brien KMKennedy CJSetiawan VWCannioto RPeters ESSieh WEtter JLPharoah PDPLeMarchand LLarson MCSalvensen HBMoorman PGWang XQBjorge LOdunsi KGentry-Maharaj AKaufmann SHSellers TACote MLBondy MKiemeney LABernardini MQVanderstichele AMoffitt MKelemen LEEdwards TLTworoger SSCook LTerry PDEccles DPeres LCRamus SThompson PJManichaikul AModugno FNess RAlberg AJCarney MEBruegl APearce CLBrooks-Wilson ABerchuck ALe NDKarlan BYVelez Edwards DRPoole EMAnton-Culver HTerry KLBandera EVDoherty JAMonteiro ANLevine DAPejovic TKeku TOHoyo CMenon UMay TPermuth-Way JBFunkhouser EMassuger LFAGHaiman CAVan Nieuwenhuysen ETone AAMoysich KSchildkraut JMZiogas ADeFazio ACramer DWMcGuire VGrant DJGayther SSandler DPVergote IHuang RYSong HBrenton JDGoodman MTWilkens LRCampbell IBarnholtz-Sloan JLambrechts DWentzensen NRothstein JHSchwartz AGBeeghly-Fadiel AWu AHWhittemore ASRossing MAGoode ELfalseEvaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significanc2019-01-01T00:00:00Z2019 May2026-05-07T04:25:51.387Z2025-05-29T20:17:43.607ZS-EPMC65369633100191710.1002/cam4.1996