biostudies-literatureHan JNational Natural Science Foundation of ChinaE1828https://www.ebi.ac.uk/biostudies/studies/S-EPMC6539882biostudies-literatureUnknown24(9)This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies.Molecules (Basel, Switzerland)Optical Resolution of Rimantadine.PMC653988221761132021 and 21606133Izawa KSato TTakeda RMoriwaki HHan JAbe HSoloshonok VAfalseOptical Resolution of Rimantadine.This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies.2019-01-01T00:00:00Z2019 May2025-04-04T09:36:08.493Z2019-07-01T13:56:23ZS-EPMC65398823108363610.3390/molecules24091828