biostudies-literatureDuval AInvestissement d'avenir programe1006496https://www.ebi.ac.uk/biostudies/studies/S-EPMC6542504biostudies-literatureUnknown15(5)Antibiotic-resistance of hospital-acquired infections is a major public health issue. The worldwide emergence and diffusion of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, including Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP), is of particular concern. Preventing their nosocomial spread requires understanding their transmission. Using Close Proximity Interactions (CPIs), measured by wearable sensors, and weekly ESBL-EC-and ESBL-KP-carriage data, we traced their possible transmission paths among 329 patients in a 200-bed long-term care facility over 4 months. Based on phenotypically defined resistance profiles to 12 antibiotics only, new bacterial acquisitions were tracked. Extending a previously proposed statistical method, the CPI network's abilityPLoS computational biologyClose proximity interactions support transmission of ESBL-K. pneumoniae but not ESBL-E. coli in healthcare settings.PMC6542504ANR-10-LABX-62-IBEIDFleury EGuillemot DTemime LBoelle PYObadia TOpatowski LHerrmann JLDuval Ai-Bird Study groupfalseClose proximity interactions support transmission of ESBL-K. pneumoniae but not ESBL-E. coli in healthcare settings.Antibiotic-resistance of hospital-acquired infections is a major public health issue. The worldwide emergence and diffusion of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, including Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP), is of particular concern. Preventing their nosocomial spread requires understanding their transmission. Using Close Proximity Interactions (CPIs), measured by wearable sensors, and weekly ESBL-EC-and ESBL-KP-carriage data, we traced their possible transmission paths among 329 patients in a 200-bed long-term care facility over 4 months. Based on phenotypically defined resistance profiles to 12 antibiotics only, new bacterial acquisitions were tracked. Extending a previously proposed statistical method, the CPI network's ability2019-01-01T00:00:00Z2019 May2026-07-14T15:04:09.511Z2019-07-24T07:07:08ZS-EPMC65425043114572510.1371/journal.pcbi.1006496