{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sacre S"],"funding":["Medical Research Council"],"pagination":["1167"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6542943"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Antidepressants are increasingly recognized to have anti-inflammatory properties in addition to their ability to treat major depressive disorders. To explore if engagement of 5-hydroxytryptamine (5-HT) receptors was required for the anti-inflammatory effect of the tetracyclic antidepressant mianserin, a series of structural derivatives were generated with the aim of reducing 5-HT receptor binding. Primary human peripheral blood mononuclear cells were used to screen for anti-inflammatory activity. The lead compound demonstrated a significant loss in 5-HT receptor binding, as assessed by non-selective 5-HT binding of radiolabelled serotonin in rat cerebral cortex. However, it retained the ability to inhibit endosomal toll-like receptor 8 signaling in primary human macrophages and spontaneous"],"journal":["Frontiers in immunology"],"pubmed_title":["Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors."],"pmcid":["PMC6542943"],"funding_grant_id":["G1001715"],"pubmed_authors":["Jaxa-Chamiec A","Sacre S","Tralau-Stewart C","Chamberlain G","Low CMR"],"additional_accession":[]},"is_claimable":false,"name":"Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors.","description":"Antidepressants are increasingly recognized to have anti-inflammatory properties in addition to their ability to treat major depressive disorders. To explore if engagement of 5-hydroxytryptamine (5-HT) receptors was required for the anti-inflammatory effect of the tetracyclic antidepressant mianserin, a series of structural derivatives were generated with the aim of reducing 5-HT receptor binding. Primary human peripheral blood mononuclear cells were used to screen for anti-inflammatory activity. The lead compound demonstrated a significant loss in 5-HT receptor binding, as assessed by non-selective 5-HT binding of radiolabelled serotonin in rat cerebral cortex. However, it retained the ability to inhibit endosomal toll-like receptor 8 signaling in primary human macrophages and spontaneous","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-18T20:39:33.489Z","creation":"2019-07-24T07:07:16Z"},"accession":"S-EPMC6542943","cross_references":{"pubmed":["31244825"],"doi":["10.3389/fimmu.2019.01167"]}}