{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie R"],"funding":["NCI NIH HHS"],"pagination":["1601-1610"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6548004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(7)"],"pubmed_abstract":["<b>Background:</b> One of our previous studies have demonstrated that the cancer suppressor miR-150 regulated the progression of colorectal cancer (CRC) by down-regulating v-myb avian myeloblastosis viral oncogene homolog (c-Myb). The purpose of present study was to evaluate the prognostic value of the expression of c-Myb and its effector, prostaglandin-endoperoxide synthase 2 (COX-2) in patients with CRC. <b>Methods:</b> We used tissue microarrays (containing 202 CRC tissues and matched adjacent normal tissues) and conducted immunohistochemical analysis and western blotting analysis (containing 3 CRC tissues and matched adjacent normal tissues) to detect the expression of c-Myb and COX-2. <b>Results:</b> Compared with the adjacent nontumorous tissues, both the expression levels of c-Myb a"],"journal":["Journal of Cancer"],"pubmed_title":["c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer."],"pmcid":["PMC6548004"],"funding_grant_id":["R01 CA202797"],"pubmed_authors":["Liu H","Li X","Yang Y","Goel A","Guo J","Wei Q","Zhang H","Qin H","Ma Y","Xie R"],"additional_accession":[]},"is_claimable":false,"name":"c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer.","description":"<b>Background:</b> One of our previous studies have demonstrated that the cancer suppressor miR-150 regulated the progression of colorectal cancer (CRC) by down-regulating v-myb avian myeloblastosis viral oncogene homolog (c-Myb). The purpose of present study was to evaluate the prognostic value of the expression of c-Myb and its effector, prostaglandin-endoperoxide synthase 2 (COX-2) in patients with CRC. <b>Methods:</b> We used tissue microarrays (containing 202 CRC tissues and matched adjacent normal tissues) and conducted immunohistochemical analysis and western blotting analysis (containing 3 CRC tissues and matched adjacent normal tissues) to detect the expression of c-Myb and COX-2. <b>Results:</b> Compared with the adjacent nontumorous tissues, both the expression levels of c-Myb a","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-06-03T16:43:11.179Z","creation":"2019-07-24T07:09:32Z"},"accession":"S-EPMC6548004","cross_references":{"pubmed":["31205515"],"doi":["10.7150/jca.27261"]}}