biostudies-literatureXie RNCI NIH HHS1601-1610https://www.ebi.ac.uk/biostudies/studies/S-EPMC6548004biostudies-literatureUnknown10(7)<b>Background:</b> One of our previous studies have demonstrated that the cancer suppressor miR-150 regulated the progression of colorectal cancer (CRC) by down-regulating v-myb avian myeloblastosis viral oncogene homolog (c-Myb). The purpose of present study was to evaluate the prognostic value of the expression of c-Myb and its effector, prostaglandin-endoperoxide synthase 2 (COX-2) in patients with CRC. <b>Methods:</b> We used tissue microarrays (containing 202 CRC tissues and matched adjacent normal tissues) and conducted immunohistochemical analysis and western blotting analysis (containing 3 CRC tissues and matched adjacent normal tissues) to detect the expression of c-Myb and COX-2. <b>Results:</b> Compared with the adjacent nontumorous tissues, both the expression levels of c-Myb aJournal of Cancerc-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer.PMC6548004R01 CA202797Liu HLi XYang YGoel AGuo JWei QZhang HQin HMa YXie Rfalsec-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer.<b>Background:</b> One of our previous studies have demonstrated that the cancer suppressor miR-150 regulated the progression of colorectal cancer (CRC) by down-regulating v-myb avian myeloblastosis viral oncogene homolog (c-Myb). The purpose of present study was to evaluate the prognostic value of the expression of c-Myb and its effector, prostaglandin-endoperoxide synthase 2 (COX-2) in patients with CRC. <b>Methods:</b> We used tissue microarrays (containing 202 CRC tissues and matched adjacent normal tissues) and conducted immunohistochemical analysis and western blotting analysis (containing 3 CRC tissues and matched adjacent normal tissues) to detect the expression of c-Myb and COX-2. <b>Results:</b> Compared with the adjacent nontumorous tissues, both the expression levels of c-Myb a2019-01-01T00:00:00Z20192026-06-03T16:43:11.179Z2019-07-24T07:09:32ZS-EPMC65480043120551510.7150/jca.27261