biostudies-literatureUnknown8(1)Poubelle PERare Disease FoundationLa Fondation du Grand défi Pierre Lavoie<h4>Background</h4>Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, classical and genetic predictors are currently unsatisfactory to predict individual response to a biologic, and the best treatment selection is still based on a trial-and-error approach. Here, we report a clinical case demonstrating the usefulness of examining the leukocytes' secretome of patients. We set up and standardized a protocol that examines a patient's immune responses to establish the secretome of the blood mononuclear leukocytes and personalize the biotherapy.<h4>Case presentation</h4>A 24-year-old woman was diagnosed with active early rheumatoid arthritis. TClinical and translational medicine19https://www.ebi.ac.uk/biostudies/studies/S-EPMC6548783biostudies-literatureThe use of leukocytes' secretome to individually target biological therapy in autoimmune arthritis: a case report.PMC6548783Sampaio Moura NTessier PAPelletier MPoubelle PEPage NLongchamps MPBeck DBAksentijevich IfalseThe use of leukocytes' secretome to individually target biological therapy in autoimmune arthritis: a case report.<h4>Background</h4>Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, classical and genetic predictors are currently unsatisfactory to predict individual response to a biologic, and the best treatment selection is still based on a trial-and-error approach. Here, we report a clinical case demonstrating the usefulness of examining the leukocytes' secretome of patients. We set up and standardized a protocol that examines a patient's immune responses to establish the secretome of the blood mononuclear leukocytes and personalize the biotherapy.<h4>Case presentation</h4>A 24-year-old woman was diagnosed with active early rheumatoid arthritis. T2019-01-01T00:00:00Z2019 Jun2025-05-18T11:18:36.949Z2025-05-18T11:18:36.949ZS-EPMC65487833116529910.1186/s40169-019-0236-7