{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":64,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Pak S"],"pubmed_abstract":["This retrospective study compared adjuvant chemotherapy (AC) versus observation after radical cystectomy (RC) in patients with node-positive bladder cancer (pN+). Outcomes were reviewed in patients with pTanyN1-3M0 bladder cancer who underwent RC with or without AC between 1995 and 2017. Baseline characteristics between the two groups were controlled with inverse probability of treatment weighting (IPTW)-adjusted analyses. Of 281 enrolled patients, the 3-year IPTW-adjusted rates of overall survival was higher in the AC group than the RC group (46.4% vs. 33.7%, p = 0.024). AC was an independent predictor of overall survival (hazard ratio = 0.48; P < 0.0001). When patients were subdivided by lymph node density (LND), the 3-year overall survival rates were similar between the AC and RC groups in patients with LND < 9%, but higher in the AC group in patients with LND 9-25% (53.4% vs. 23.7%) and LND ≥ 25% (27.4% vs. 16.1%). The numbers needed to treat to prevent one death at 3 years were three and nine in patients with LND 9-25% and ≥25%, respectively. In conclusion, AC after RC was associated with improved overall survival in patients with node-positive bladder cancer. Patients with an intermediate nodal burden may benefit most from AC."],"journal":["Scientific reports"],"pagination":["8305"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6549178"],"repository":["biostudies-literature"],"pubmed_title":["Adjuvant chemotherapy versus observation after radical cystectomy in patients with node-positive bladder cancer."],"pmcid":["PMC6549178"],"pubmed_authors":["Jeong IG","Kim CS","Hong JH","Pak S","You D","Song C","Lee JL","Ahn H","Hong B"],"view_count":["64"],"additional_accession":[]},"is_claimable":false,"name":"Adjuvant chemotherapy versus observation after radical cystectomy in patients with node-positive bladder cancer.","description":"This retrospective study compared adjuvant chemotherapy (AC) versus observation after radical cystectomy (RC) in patients with node-positive bladder cancer (pN+). Outcomes were reviewed in patients with pTanyN1-3M0 bladder cancer who underwent RC with or without AC between 1995 and 2017. Baseline characteristics between the two groups were controlled with inverse probability of treatment weighting (IPTW)-adjusted analyses. Of 281 enrolled patients, the 3-year IPTW-adjusted rates of overall survival was higher in the AC group than the RC group (46.4% vs. 33.7%, p = 0.024). AC was an independent predictor of overall survival (hazard ratio = 0.48; P < 0.0001). When patients were subdivided by lymph node density (LND), the 3-year overall survival rates were similar between the AC and RC groups in patients with LND < 9%, but higher in the AC group in patients with LND 9-25% (53.4% vs. 23.7%) and LND ≥ 25% (27.4% vs. 16.1%). The numbers needed to treat to prevent one death at 3 years were three and nine in patients with LND 9-25% and ≥25%, respectively. In conclusion, AC after RC was associated with improved overall survival in patients with node-positive bladder cancer. Patients with an intermediate nodal burden may benefit most from AC.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2024-12-03T18:14:59.545Z","creation":"2019-07-24T07:09:57Z"},"accession":"S-EPMC6549178","cross_references":{"pubmed":["31165753"],"doi":["10.1038/s41598-019-44504-9"]}}