{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(1)"],"submitter":["Randeria SN"],"funding":["South African National Research Foundation"],"pubmed_abstract":["<h4>Background</h4>The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic inflammation, with the accompanying presence of circulating and dysregulated inflammatory biomarkers; which in turn is associated with abnormal clot formation.<h4>Methods</h4>Here, we investigate the correlation between abnormal blood clotting, using thromboelastography (TEG), clot ultrastructure using scanning electron microscopy (SEM) and the presence of a dysregulated inflammatory cytokine profile, by examining various circulating biomarkers.<h4>Results</h4>Our results show that many biomarkers, across TEG, cytokine and lipid groups, were greatly dysregulated in the "],"journal":["Cardiovascular diabetology"],"pagination":["72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6549308"],"repository":["biostudies-literature"],"pubmed_title":["Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation."],"pmcid":["PMC6549308"],"pubmed_authors":["Roberts T","Randeria SN","Nell TA","Pretorius E","Thomson GJA"],"additional_accession":[]},"is_claimable":false,"name":"Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation.","description":"<h4>Background</h4>The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic inflammation, with the accompanying presence of circulating and dysregulated inflammatory biomarkers; which in turn is associated with abnormal clot formation.<h4>Methods</h4>Here, we investigate the correlation between abnormal blood clotting, using thromboelastography (TEG), clot ultrastructure using scanning electron microscopy (SEM) and the presence of a dysregulated inflammatory cytokine profile, by examining various circulating biomarkers.<h4>Results</h4>Our results show that many biomarkers, across TEG, cytokine and lipid groups, were greatly dysregulated in the ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-19T14:27:37.765Z","creation":"2019-07-24T07:10:02Z"},"accession":"S-EPMC6549308","cross_references":{"pubmed":["31164120"],"doi":["10.1186/s12933-019-0870-9"]}}