biostudies-literatureUnknown18(1)Randeria SNSouth African National Research Foundation<h4>Background</h4>The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic inflammation, with the accompanying presence of circulating and dysregulated inflammatory biomarkers; which in turn is associated with abnormal clot formation.<h4>Methods</h4>Here, we investigate the correlation between abnormal blood clotting, using thromboelastography (TEG), clot ultrastructure using scanning electron microscopy (SEM) and the presence of a dysregulated inflammatory cytokine profile, by examining various circulating biomarkers.<h4>Results</h4>Our results show that many biomarkers, across TEG, cytokine and lipid groups, were greatly dysregulated in the Cardiovascular diabetology72https://www.ebi.ac.uk/biostudies/studies/S-EPMC6549308biostudies-literatureInflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation.PMC6549308Roberts TRanderia SNNell TAPretorius EThomson GJAfalseInflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation.<h4>Background</h4>The global burden of type 2 diabetes mellitus (T2DM), together with the presence of cardiovascular risk in this population, is reaching pandemic levels. A prominent feature of T2DM is chronic and systemic inflammation, with the accompanying presence of circulating and dysregulated inflammatory biomarkers; which in turn is associated with abnormal clot formation.<h4>Methods</h4>Here, we investigate the correlation between abnormal blood clotting, using thromboelastography (TEG), clot ultrastructure using scanning electron microscopy (SEM) and the presence of a dysregulated inflammatory cytokine profile, by examining various circulating biomarkers.<h4>Results</h4>Our results show that many biomarkers, across TEG, cytokine and lipid groups, were greatly dysregulated in the 2019-01-01T00:00:00Z2019 Jun2025-04-19T14:27:37.765Z2019-07-24T07:10:02ZS-EPMC65493083116412010.1186/s12933-019-0870-9