biostudies-literatureZhang YPudong New area science and technology development foundationScience and Technology Commission of Shanghai MunicipalityShanghai Shen Kang Hospital Development CenterNational Natural Science Foundation of ChinaNational Key Research and Development Program of China94https://www.ebi.ac.uk/biostudies/studies/S-EPMC6549341biostudies-literatureUnknown14(1)<h4>Purpose</h4>To assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual function.<h4>Methods</h4>Sixty-four patients with localized prostate cancer admitted from July 2015 to January 2018 underwent CIRT. At baseline and 5 time-points after radiotherapy, we assessed patients' QOL using the 26-item edition of the Expanded Prostate Cancer Index-Composite (EPIC-26) Chinese version. Logistic regression was performed to identify clinical factors associated with acute genitourinary (GU) toxicity and relative QOL.<h4>Results</h4>By the end of CIRT, urinary irritation/obstruction temporarily declined (- 7.92 ± 1.76, p < .001). For urinary incontinRadiation oncology (London, England)Preliminary exploration of clinical factors affecting acute toxicity and quality of life after carbon ion therapy for prostate cancer.PMC6549341154119501042017YFC010760081773225PKJ2016-Y4316CR3097BFu SZhang YYu QWu SLi PChen XZhang QfalsePreliminary exploration of clinical factors affecting acute toxicity and quality of life after carbon ion therapy for prostate cancer.<h4>Purpose</h4>To assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual function.<h4>Methods</h4>Sixty-four patients with localized prostate cancer admitted from July 2015 to January 2018 underwent CIRT. At baseline and 5 time-points after radiotherapy, we assessed patients' QOL using the 26-item edition of the Expanded Prostate Cancer Index-Composite (EPIC-26) Chinese version. Logistic regression was performed to identify clinical factors associated with acute genitourinary (GU) toxicity and relative QOL.<h4>Results</h4>By the end of CIRT, urinary irritation/obstruction temporarily declined (- 7.92 ± 1.76, p < .001). For urinary incontin2019-01-01T00:00:00Z2019 Jun2025-04-19T03:26:56.17Z2019-07-24T07:10:04ZS-EPMC65493413116417210.1186/s13014-019-1303-3