biostudies-literatureAbe TJapanese Association for Acute Medicine202https://www.ebi.ac.uk/biostudies/studies/S-EPMC6551884biostudies-literatureUnknown23(1)<h4>Background</h4>Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aimed to investigate the relationship between misdiagnosis of the site of infection at initial examination and in-hospital mortality.<h4>Methods</h4>This was a secondary-multicenter prospective cohort study involving 37 emergency departments. Consecutive adult patients with infection from December 2017 to February 2018 were included. Misdiagnosis of the site of infection was defined as a discrepancy between the suspected site of infection at initial examination and that at final diagnosis, including those infections remaining unidentified during hospital admission, wherCritical care (London, England)In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission.PMC65518842014-01Sasaki JMaehara JAnan HSugita MDeshpande GAShiraishi SIYoshihara HShiraishi AMiki YHoshino ATakeyama NMuroya TKittaka HSugiyama TTokuda YIshikura HYamaguchi HKotani JDeguchi YKiyota KYamashita HKawakami MOkada KOkamoto KFujishima SOtomo YJAAM SPICE Study GroupHanaki YHarada MKaneko TTakuma KHagiwara AGando SSakamoto YYamakawa KNachi SMorino KMayumi THifumi TAbe TKoike KShimizu YShiino YfalseIn-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission.<h4>Background</h4>Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aimed to investigate the relationship between misdiagnosis of the site of infection at initial examination and in-hospital mortality.<h4>Methods</h4>This was a secondary-multicenter prospective cohort study involving 37 emergency departments. Consecutive adult patients with infection from December 2017 to February 2018 were included. Misdiagnosis of the site of infection was defined as a discrepancy between the suspected site of infection at initial examination and that at final diagnosis, including those infections remaining unidentified during hospital admission, wher2019-01-01T00:00:00Z2019 Jun2025-04-22T15:09:41.743Z2019-07-24T07:10:56ZS-EPMC65518843117100610.1186/s13054-019-2475-9