{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(5)"],"submitter":["Yoon W"],"pubmed_abstract":["The function of AarF domain-containing kinase 1 (ADCK1) has not been thoroughly revealed. Here we identified that ADCK1 utilizes YME1-like 1 ATPase (YME1L1) to control optic atrophy 1 (OPA1) and inner membrane mitochondrial protein (IMMT) in regulating mitochondrial dynamics and cristae structure. We firstly observed that a serious developmental impairment occurred in Drosophila ADCK1 (dADCK1) deletion mutant, resulting in premature death before adulthood. By using temperature sensitive ubiquitously expression driver tub-Gal80ts/tub-Gal4 or muscle-specific expression driver mhc-Gal4, we observed severely defective locomotive activities and structural abnormality in the muscle along with increased mitochondrial fusion in the dADCK1 knockdown flies. Moreover, decreased mitochondrial membrane"],"journal":["PLoS genetics"],"pagination":["e1008184"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6553794"],"repository":["biostudies-literature"],"pubmed_title":["Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle."],"pmcid":["PMC6553794"],"pubmed_authors":["Yoon W","Hwang SH","Lee SH","Chung J"],"additional_accession":[]},"is_claimable":false,"name":"Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle.","description":"The function of AarF domain-containing kinase 1 (ADCK1) has not been thoroughly revealed. Here we identified that ADCK1 utilizes YME1-like 1 ATPase (YME1L1) to control optic atrophy 1 (OPA1) and inner membrane mitochondrial protein (IMMT) in regulating mitochondrial dynamics and cristae structure. We firstly observed that a serious developmental impairment occurred in Drosophila ADCK1 (dADCK1) deletion mutant, resulting in premature death before adulthood. By using temperature sensitive ubiquitously expression driver tub-Gal80ts/tub-Gal4 or muscle-specific expression driver mhc-Gal4, we observed severely defective locomotive activities and structural abnormality in the muscle along with increased mitochondrial fusion in the dADCK1 knockdown flies. Moreover, decreased mitochondrial membrane","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2026-06-20T03:13:59.054Z","creation":"2019-07-25T07:17:29Z"},"accession":"S-EPMC6553794","cross_references":{"pubmed":["31125351"],"doi":["10.1371/journal.pgen.1008184"]}}