{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ganesan P"],"funding":["NHLBI NIH HHS","National Heart and Lung Institute"],"pagination":["758-768"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6554033"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(5)"],"pubmed_abstract":["<h4>Introduction</h4>Targeting repeating-pattern atrial fibrillation (AF) sources (reentry or focal drivers) can help in patient-specific ablation therapy for AF; however, the development of reliable and accurate tools for locating such sources remains a major challenge. We describe iterative catheter navigation (ICAN) algorithm to locate AF drivers using a conventional circular Lasso catheter.<h4>Methods and results</h4>At each step, the algorithm analyzes 10 bipolar electrograms recoded at a given catheter location and the history of previous catheter movements to determine if the source is inside the catheter loop. If not, it calculates new coordinates and selects a new position for the catheter. The process continues until a source is located. The algorithm was evaluated in a computer model of atrial tissue with various degrees of fibrosis under a broad range of arrhythmia scenarios. The latter included slow and fast reentry, macroreentry, figure-of-eight reentry, and fibrillatory conduction. Depending on the initial distance of the catheter from the source and scenario, it took about 3 to 16 steps to localize an AF source. In 94% of cases, the identified location was within 4 mm from the source, independently of the initial position of the catheter. The algorithm worked equally well in the presence of patchy fibrosis, low-voltage areas, fragmented electrograms, and dominant-frequency gradients.<h4>Conclusions</h4>AF repeating-pattern sources can be localized using circular catheters without the need to map the entire tissue. The proposed algorithm has the potential to become a useful tool for patient-specific ablation of AF sources located outside the pulmonary veins."],"journal":["Journal of cardiovascular electrophysiology"],"pubmed_title":["Iterative navigation of multipole diagnostic catheters to locate repeating-pattern atrial fibrillation drivers."],"pmcid":["PMC6554033"],"funding_grant_id":["HL127663","R15 HL127663"],"pubmed_authors":["Cherry EM","Huang DT","Pertsov AM","Ghoraani B","Ganesan P","Salmin A"],"additional_accession":[]},"is_claimable":false,"name":"Iterative navigation of multipole diagnostic catheters to locate repeating-pattern atrial fibrillation drivers.","description":"<h4>Introduction</h4>Targeting repeating-pattern atrial fibrillation (AF) sources (reentry or focal drivers) can help in patient-specific ablation therapy for AF; however, the development of reliable and accurate tools for locating such sources remains a major challenge. We describe iterative catheter navigation (ICAN) algorithm to locate AF drivers using a conventional circular Lasso catheter.<h4>Methods and results</h4>At each step, the algorithm analyzes 10 bipolar electrograms recoded at a given catheter location and the history of previous catheter movements to determine if the source is inside the catheter loop. If not, it calculates new coordinates and selects a new position for the catheter. The process continues until a source is located. The algorithm was evaluated in a computer model of atrial tissue with various degrees of fibrosis under a broad range of arrhythmia scenarios. The latter included slow and fast reentry, macroreentry, figure-of-eight reentry, and fibrillatory conduction. Depending on the initial distance of the catheter from the source and scenario, it took about 3 to 16 steps to localize an AF source. In 94% of cases, the identified location was within 4 mm from the source, independently of the initial position of the catheter. The algorithm worked equally well in the presence of patchy fibrosis, low-voltage areas, fragmented electrograms, and dominant-frequency gradients.<h4>Conclusions</h4>AF repeating-pattern sources can be localized using circular catheters without the need to map the entire tissue. The proposed algorithm has the potential to become a useful tool for patient-specific ablation of AF sources located outside the pulmonary veins.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2024-11-06T11:20:32.514Z","creation":"2020-05-21T18:59:32Z"},"accession":"S-EPMC6554033","cross_references":{"pubmed":["30725499"],"doi":["10.1111/jce.13872"]}}