{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mehta HH"],"funding":["NIA NIH HHS","U.S. Department of Defense","National Institute on Aging"],"pagination":["88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6554247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(6)"],"pubmed_abstract":["<h4>Introduction</h4>The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modulate metabolism.<h4>Objectives</h4>By using a metabolomic approach, this study explores how the plasma metabolite profile is regulated in response to humanin and SHLP2 treatment in a diet-induced obesity (DIO) mouse model. The results also shed light on the potential mechanism underlying MDPs' insulin sensitization effects.<h4>Methods</h4>Plasma samples were obtained from DIO mice subjected to vehicle (water) treatment, or peptide treatment with either humanin analog S14G (HNG) or SHLP2 (n = 6 per group). Ve"],"journal":["Metabolomics : Official journal of the Metabolomic Society"],"pubmed_title":["Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment."],"pmcid":["PMC6554247"],"funding_grant_id":["PC160353","P01AG034906","RF1 AG061834","T32 AG000037","P01 AG055369","R01AG034430"],"pubmed_authors":["Cohen P","Mehta HH","Xiao J","Yen K","Ramirez R","Kim SJ","Miller B"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.","description":"<h4>Introduction</h4>The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modulate metabolism.<h4>Objectives</h4>By using a metabolomic approach, this study explores how the plasma metabolite profile is regulated in response to humanin and SHLP2 treatment in a diet-induced obesity (DIO) mouse model. The results also shed light on the potential mechanism underlying MDPs' insulin sensitization effects.<h4>Methods</h4>Plasma samples were obtained from DIO mice subjected to vehicle (water) treatment, or peptide treatment with either humanin analog S14G (HNG) or SHLP2 (n = 6 per group). Ve","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-04T11:06:56.368Z","creation":"2019-07-24T07:11:16Z"},"accession":"S-EPMC6554247","cross_references":{"pubmed":["31172328"],"doi":["10.1007/s11306-019-1549-7"]}}