{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Salo KI"],"funding":["Westfälische Wilhelms-Universität Münster"],"pubmed_abstract":["<b>Background:</b> The <i>vascular depression hypothesis</i> emphasizes the significance of vascular lesions in late-life depression. At present, no meta-analytic model has investigated whether a difference in hyperintensity burden compared to controls between late-life and late-onset depression is evident. By including a substantial number of studies, focusing on a meaningful outcome measure, and considering several moderating and control variables, the present meta-analysis investigates the severity of hyperintensity burden in major depressive disorder (MDD) and bipolar disorder (BD). A major focus of the present meta-analysis refers to the role of age at illness onset. It is analyzed whether late-onset rather than late-life depression characterizes vascular depression. <b>Method:</b> In"],"journal":["Frontiers in psychology"],"pagination":["1241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6555192"],"repository":["biostudies-literature"],"pubmed_title":["Confining the Concept of Vascular Depression to Late-Onset Depression: A Meta-Analysis of MRI-Defined Hyperintensity Burden in Major Depressive Disorder and Bipolar Disorder."],"pmcid":["PMC6555192"],"pubmed_authors":["Scharfen J","Holling H","Wilden ID","Salo KI","Schubotz RI"],"additional_accession":[]},"is_claimable":false,"name":"Confining the Concept of Vascular Depression to Late-Onset Depression: A Meta-Analysis of MRI-Defined Hyperintensity Burden in Major Depressive Disorder and Bipolar Disorder.","description":"<b>Background:</b> The <i>vascular depression hypothesis</i> emphasizes the significance of vascular lesions in late-life depression. At present, no meta-analytic model has investigated whether a difference in hyperintensity burden compared to controls between late-life and late-onset depression is evident. By including a substantial number of studies, focusing on a meaningful outcome measure, and considering several moderating and control variables, the present meta-analysis investigates the severity of hyperintensity burden in major depressive disorder (MDD) and bipolar disorder (BD). A major focus of the present meta-analysis refers to the role of age at illness onset. It is analyzed whether late-onset rather than late-life depression characterizes vascular depression. <b>Method:</b> In","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-18T18:39:50.681Z","creation":"2019-07-24T07:11:38Z"},"accession":"S-EPMC6555192","cross_references":{"pubmed":["31214072"],"doi":["10.3389/fpsyg.2019.01241"]}}