{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maksymetz J"],"funding":["Bristol-Myers Squibb","NICHD NIH HHS","NIMH NIH HHS","CHDI Foundation","National Institutes of Health","Canadian Institutes for Health Research","Johnson and Johnson","CIHR","Dystonia Medical Research Foundation","Michael J. Fox Foundation","Vanderbilt International Scholars Program","NINDS NIH HHS","AstraZeneca","Seaside Therapeutics"],"pagination":["989-1000"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6555658"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["85(12)"],"pubmed_abstract":["<h4>Background</h4>The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder, PFC hyperactivity is associated with inappropriate fear in safe situations. We previously reported a form of muscarinic acetylcholine receptor (mAChR)-dependent long-term depression in the PFC that we hypothesize is involved in appropriate fear responding and could serve to reduce cortical hyperactivity following stress. However, it is unknown whether this long-term depression occurs at fear-related inputs.<h4>Methods</h4>Using optogenetics with extracellular and whole-cell electrophysiology, we assessed the effect of mAChR activation on the synaptic strengt"],"journal":["Biological psychiatry"],"pubmed_title":["M<sub>1</sub> Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder."],"pmcid":["PMC6555658"],"funding_grant_id":["U54 HD083211","R01 NS069689","U19 MH106839","R01 MH073676","CIHR DFS146189","DFS146189","R37 NS031373","R01 MH062646"],"pubmed_authors":["Moran SP","Maksymetz J","Engers DW","Conn PJ","Lindsley CW","Stansley BJ","Li B","Joffe ME","Temple K","Lawrence JJ"],"additional_accession":[]},"is_claimable":false,"name":"M<sub>1</sub> Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder.","description":"<h4>Background</h4>The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder, PFC hyperactivity is associated with inappropriate fear in safe situations. We previously reported a form of muscarinic acetylcholine receptor (mAChR)-dependent long-term depression in the PFC that we hypothesize is involved in appropriate fear responding and could serve to reduce cortical hyperactivity following stress. However, it is unknown whether this long-term depression occurs at fear-related inputs.<h4>Methods</h4>Using optogenetics with extracellular and whole-cell electrophysiology, we assessed the effect of mAChR activation on the synaptic strengt","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2026-05-02T09:41:47.76Z","creation":"2020-06-18T07:01:28Z"},"accession":"S-EPMC6555658","cross_references":{"pubmed":["31003787"],"doi":["10.1016/j.biopsych.2019.02.020"]}}