biostudies-literatureMyte RVästerbotten Läns LandstingMedicinska fakulteten, Umeå UniversitetSvenska LäkaresällskapetLion’s Cancer Research Foundation, Umeå UniversityCancer Research Foundation in Northern Sweden649-659https://www.ebi.ac.uk/biostudies/studies/S-EPMC6557598biostudies-literatureUnknown14(7)DNA methylation in blood may adapt to conditions affecting our health, such as inflammation, and multiple studies have identified differential DNA methylation related to smoking, obesity and various diseases. The purpose of this study was to evaluate previously reported, and explore possible new, associations between levels of inflammatory markers and DNA methylation in blood. We used a well-characterized study population consisting of 127 individuals, all of whom were participants in the population-based Västerbotten Intervention Programme cohort and had provided two blood samples, ten years apart. Levels of CRP and 160 other proteins were measured in plasma, and DNA methylation levels (assessed using the 850K Illumina Infinium MethylationEPIC BeadChip) were measured in white blood cell DEpigeneticsCirculating levels of inflammatory markers and DNA methylation, an analysis of repeated samples from a population based cohort.PMC6557598VLL-547711, VLL-680921 and VLL-582691LP 17-2157, LP 16-2124 and LP 15-2075NAAMP 17-866SLS-594811Sundkvist AMyte RVan Guelpen BHarlid SfalseCirculating levels of inflammatory markers and DNA methylation, an analysis of repeated samples from a population based cohort.DNA methylation in blood may adapt to conditions affecting our health, such as inflammation, and multiple studies have identified differential DNA methylation related to smoking, obesity and various diseases. The purpose of this study was to evaluate previously reported, and explore possible new, associations between levels of inflammatory markers and DNA methylation in blood. We used a well-characterized study population consisting of 127 individuals, all of whom were participants in the population-based Västerbotten Intervention Programme cohort and had provided two blood samples, ten years apart. Levels of CRP and 160 other proteins were measured in plasma, and DNA methylation levels (assessed using the 850K Illumina Infinium MethylationEPIC BeadChip) were measured in white blood cell D2019-01-01T00:00:00Z2019 Jul2025-04-04T22:08:58.846Z2019-07-24T07:13:44ZS-EPMC65575983103341110.1080/15592294.2019.1603962