{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo Z"],"funding":["Science and Technology Planning Project of Guangdong Province","Strategic Priority Research Program of the Chinese Academy of Sciences","Guangzhou Science and Technology Program","Guangdong Province Science and Technology Program","Zhujiang Talents-Overseas Young Talents Postdoctoral Fellowship","National Key Research and Development Program of China","National Natural Science Foundation of China"],"pagination":["21-29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6557759"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Class IIa histone deacetylases (HDACs) are a subfamily of HDACs with important functions in development and adult tissue homeostasis. As opposed to other HDACs, they lack catalytic function and bind transcription factors to recruit transcriptional co-regulators, mostly co-repressors such as nuclear receptor co-repressor (NCoR)/silencing mediator of retinoid and thyroid hormone receptor (SMRT). Class IIa HDACs enhance mouse somatic cell reprogramming to induced pluripotent stem cells (iPSCs) by repressing the function of the pro-mesenchymal transcription factor myocyte enhancer factor 2 (MEF2), which is upregulated during this process. Here, we describe, using HDAC4 and 7 as examples, that class IIa HDACs exhibit nuclear-cytoplasmic trafficking in reprogramming, being mostly cytoplasmic in "],"journal":["Cell regeneration (London, England)"],"pubmed_title":["Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming."],"pmcid":["PMC6557759"],"funding_grant_id":["2014A030312001","XDA16030502","81571238","2016B030229007","31671537","201807010066","2017B050506007","2017B030314056","31571524","2018YFA0106903","2016YFA0100102"],"pubmed_authors":["Luo Z","Zhang H","Volpe G","Zhuang Q","Zhang M","Zhong X","Wang L","Esteban MA","Li W","Lai Y","Huang Y","Huang Z","Qing X","Benda C","Ward C","Qin B"],"additional_accession":[]},"is_claimable":false,"name":"Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming.","description":"Class IIa histone deacetylases (HDACs) are a subfamily of HDACs with important functions in development and adult tissue homeostasis. As opposed to other HDACs, they lack catalytic function and bind transcription factors to recruit transcriptional co-regulators, mostly co-repressors such as nuclear receptor co-repressor (NCoR)/silencing mediator of retinoid and thyroid hormone receptor (SMRT). Class IIa HDACs enhance mouse somatic cell reprogramming to induced pluripotent stem cells (iPSCs) by repressing the function of the pro-mesenchymal transcription factor myocyte enhancer factor 2 (MEF2), which is upregulated during this process. Here, we describe, using HDAC4 and 7 as examples, that class IIa HDACs exhibit nuclear-cytoplasmic trafficking in reprogramming, being mostly cytoplasmic in ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-04T22:09:07.956Z","creation":"2019-07-24T07:13:51Z"},"accession":"S-EPMC6557759","cross_references":{"pubmed":["31205685"],"doi":["10.1016/j.cr.2018.11.001"]}}