biostudies-literatureLuo ZScience and Technology Planning Project of Guangdong ProvinceStrategic Priority Research Program of the Chinese Academy of SciencesGuangzhou Science and Technology ProgramGuangdong Province Science and Technology ProgramZhujiang Talents-Overseas Young Talents Postdoctoral FellowshipNational Key Research and Development Program of ChinaNational Natural Science Foundation of China21-29https://www.ebi.ac.uk/biostudies/studies/S-EPMC6557759biostudies-literatureUnknown8(1)Class IIa histone deacetylases (HDACs) are a subfamily of HDACs with important functions in development and adult tissue homeostasis. As opposed to other HDACs, they lack catalytic function and bind transcription factors to recruit transcriptional co-regulators, mostly co-repressors such as nuclear receptor co-repressor (NCoR)/silencing mediator of retinoid and thyroid hormone receptor (SMRT). Class IIa HDACs enhance mouse somatic cell reprogramming to induced pluripotent stem cells (iPSCs) by repressing the function of the pro-mesenchymal transcription factor myocyte enhancer factor 2 (MEF2), which is upregulated during this process. Here, we describe, using HDAC4 and 7 as examples, that class IIa HDACs exhibit nuclear-cytoplasmic trafficking in reprogramming, being mostly cytoplasmic in Cell regeneration (London, England)Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming.PMC65577592014A030312001XDA16030502815712382016B030229007316715372018070100662017B0505060072017B030314056315715242018YFA01069032016YFA0100102Luo ZZhang HVolpe GZhuang QZhang MZhong XWang LEsteban MALi WLai YHuang YHuang ZQing XBenda CWard CQin BfalseNuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming.Class IIa histone deacetylases (HDACs) are a subfamily of HDACs with important functions in development and adult tissue homeostasis. As opposed to other HDACs, they lack catalytic function and bind transcription factors to recruit transcriptional co-regulators, mostly co-repressors such as nuclear receptor co-repressor (NCoR)/silencing mediator of retinoid and thyroid hormone receptor (SMRT). Class IIa HDACs enhance mouse somatic cell reprogramming to induced pluripotent stem cells (iPSCs) by repressing the function of the pro-mesenchymal transcription factor myocyte enhancer factor 2 (MEF2), which is upregulated during this process. Here, we describe, using HDAC4 and 7 as examples, that class IIa HDACs exhibit nuclear-cytoplasmic trafficking in reprogramming, being mostly cytoplasmic in 2019-01-01T00:00:00Z2019 Jun2025-04-04T22:09:07.956Z2019-07-24T07:13:51ZS-EPMC65577593120568510.1016/j.cr.2018.11.001